77621-73-9Relevant articles and documents
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers
Mollica, Adriano,Davis, Peg,Ma, Shou-Wu,Lai, Josephine,Porreca, Frank,Hruby, Victor J.
, p. 2471 - 2475 (2007/10/03)
Biphalin is a potent opioid peptide agonist, with a palandromic structure, composed of two enkephalin-like active fragments connected tail to tail by a hydrazine linker (Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Gly-D-Ala-Tyr). This study presents the synthesis and
Design and Synthesis of Enkephalin Analogues: Part II - Synthesis of 2, Met5>-Enkephalin Alkylamides Having Morphinomimetic Activity
Dhotre, B. J.,Mathur, K. B.
, p. 1231 - 1236 (2007/10/02)
Alkylamides of 2, Met5>-enkephalin have been synthesized by two different routes.The first method consists of the sequential peptidation of Phe-Met-ONBzl by 2,4,5-trichlorophenyl esters of Boc-Gly, Boc-D-Ala and Boc-Tyr to get