64410-47-5Relevant articles and documents
Hydrazone linker as a useful tool for preparing chimeric peptide/ Nonpeptide bifunctional compounds
Dyniewicz, Jolanta,Lipinski, Piotr F. J.,Kosson, Piotr,Lesniak, Anna,Bochynska-Czyz, Marta,Muchowska, Adriana,Tourwe, Dirk,Ballet, Steven,Misicka, Aleksandra,Lipkowski, Andrzej W.
, p. 73 - 77 (2017/12/12)
The area of multitarget compounds, joining two pharmacophores within one molecule, is a vivid field of research in medicinal chemistry. Not only pharmacophoric elements are essential for the design and activity of such compounds, but the type and length o
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers
Mollica, Adriano,Davis, Peg,Ma, Shou-Wu,Lai, Josephine,Porreca, Frank,Hruby, Victor J.
, p. 2471 - 2475 (2007/10/03)
Biphalin is a potent opioid peptide agonist, with a palandromic structure, composed of two enkephalin-like active fragments connected tail to tail by a hydrazine linker (Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Gly-D-Ala-Tyr). This study presents the synthesis and
Investigation of the structural parameters involved in the μ and δ opioid receptor discrimination of linear enkephalin-related peptides
Gacel,Zajac,Delay-Goyet,Dauge,Roques
, p. 374 - 383 (2007/10/02)
The previous rules proposed for selective recognition of μ and δ opioid receptors by modified enkephalins were investigated through an extensive structure-activity study. Thus, modifications of the sequence of TRIMU 4 (Tyr-D-Ala-Gly-NHCH(CH3)CH