776293-17-5Relevant academic research and scientific papers
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors
Zhang, Xiaojun,Glunz, Peter W.,Jiang, Wen,Schmitt, Aaron,Newman, Makenzie,Barbera, Frank A.,Bozarth, Jeffery M.,Rendina, Alan R.,Wei, Anzhi,Wen, Xiao,Rossi, Karen A.,Luettgen, Joseph M.,Wong, Pancras C.,Knabb, Robert M.,Wexler, Ruth R.,Scott Priestley
, p. 1604 - 1607 (2013/04/10)
Bicyclic pyrazinone and pyrimidinone amides were designed and synthesized as potent TF-FVIIa inhibitors. SAR demonstrated that the S2 and S3 pockets of FVIIa prefer to bind small, lipophilic groups. An X-ray crystal structure of optimized compound 9b boun
