776296-12-9

Basic information

• Product Name: 5-Bromo-3-methyoxy-quinoline
• Synonyms: 5-Bromo-3-methyoxy-quinoline;5-BroMo-3-Methoxyquinoline, 96%;EOS-61482
• CAS NO: 776296-12-9
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238
• Mol File: 776296-12-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Bromo-3-methyoxy-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-methyoxy-quinoline(776296-12-9)
• EPA Substance Registry System: 5-Bromo-3-methyoxy-quinoline(776296-12-9)

Safety Data

• Hazardous Substances Data: 776296-12-9(Hazardous Substances Data)

Upstream product

• 6931-17-5 3-methoxyquinoline 
• 101861-59-0 3,5-dibromoquinoline 
• 124-41-4 sodium methylate 
• 5332-24-1 3-bromoquinoline 

Downstream Products

• 877457-51-7 [3-(3-methoxy-quinolin-5-ylcarbamoyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester 
• 881656-52-6 3-methoxy-quinoline-5-carbaldehyde 

Relevant articles and documents

Synthetic method of 3-methoxyquinoline-5-amine

The embodiment of the invention discloses a synthesis method of 3-methoxyquinoline-5-amine, relates to the technical field of synthesis of heterocyclic compounds, and aims to effectively synthesize the 3-methoxyquinoline-5-amine. The synthesis method comprises the following steps: taking 5-bromo-3-methoxyquinoline and benzophenone imine as raw materials, carrying out a coupling reaction at 45-120 DEG C to obtain an intermediate compound, and treating the intermediate compound at 25-30 DEG C by using hydroxylamine hydrochloride under an alkaline condition to obtain 3-methoxyquinoline-5 amine. The synthesis method provided by the embodiment of the invention is used for synthesizing the quinoline compound.

Mapping the reactivity of the quinoline ring-system – Synthesis of the tetracyclic ring-system of isocryptolepine and regioisomers

Bromoquinolines (2-bromoquinoline – 8-bromoquinoline and 5-bromo-3-methoxyquinoline) and 2-aminophenylboronic acid hydrochloride were subjected to Suzuki-Miyaura cross-coupling conditions resulting in formation of the desired biaryl systems in good yields. The resulting biaryls were then subjected to palladium catalyzed C–H activation/C–N bond formation utilizing PdCl2(dppf). The reactions revealed large differences in reactivity depending on the attachment point for the 2-aminophenyl group on the quinoline. The variation in the reactivity was rationalized based on the electron distribution around the quinoline ring-system.

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential