776315-23-2Relevant academic research and scientific papers
Three-Component Dynamic Covalent Chemistry: From Janus Small Molecules to Functional Polymers
Liu, Hongxu,Lu, Hung-Hsun,Thayumanavan, S.,Zhuang, Jiaming
supporting information, p. 20735 - 20746 (2021/12/17)
A new multicomponent reaction involving 2-hydroxybenzaldehyde, amine, and 2-mercaptobenzaldehyde (HAM reaction) has been developed and applied to multicomponent polymerization and controlled radical polymerization for the construction of random and block copolymers. This chemistry features mild reaction conditions, high yield, simple isolation, and water as the only byproduct. With the advantages of the distinct nucleophilicity of thiol and hydroxyl groups, the chemistry could be used for stepwise labeling and modifications on primary amines. The Janus chemical joint formed from this reaction exhibits degradability in buffers and generates the corresponding starting reagents, allowing amine release. Interestingly, the chemical joint exhibits thermally activated reversibility with water as the catalyst. This multicomponent dynamic covalent feature has been applied to the metamorphosis of random and block copolymers, generating polymers with diverse architectures. This chemistry is expected to be broadly applicable to synthetic polymer chemistry and materials science.
INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER
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Paragraph 0180; 0182; 0196, (2020/04/21)
The invention relates to compounds of formula (I): wherein R1; R2, R3, R4, R5 and are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD interaction and thu
Oxidation of aromatic and aliphatic aldehydes to carboxylic acids by Geotrichum candidum aldehyde dehydrogenase
Hoshino, Tomoyasu,Yamabe, Emi,Hawari, Muhammad Arisyi,Tamura, Mayumi,Kanamaru, Shuji,Yoshida, Keisuke,Koesoema, Afifa Ayu,Matsuda, Tomoko
, (2020/07/20)
Oxidation reaction is one of the most important and indispensable organic reactions, so that green and sustainable catalysts for oxidation are necessary to be developed. Herein, biocatalytic oxidation of aldehydes was investigated, resulted in the synthesis of both aromatic and aliphatic carboxylic acids using a Geotrichum candidum aldehyde dehydrogenase (GcALDH). Moreover, selective oxidation of dialdehydes to aldehydic acids by GcALDH was also successful.
Method for synthesizing 1-oxo-1,3-dihydro-3-hydroxybenzofuran-5-carboxylic acid
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, (2019/12/25)
The invention discloses a method for synthesizing 1-oxo-1,3-dihydro-3-hydroxybenzofuran-5-carboxylic acid. The synthesis method comprises the following steps: mixing 2,5-dihalotoluene, glacial aceticacid, acetic anhydride and concentrated sulfuric acid, a
Mimic of the green fluorescent protein β-barrel: Photophysics and dynamics of confined chromophores defined by a rigid porous scaffold
Williams, Derek E.,Dolgopolova, Ekaterina A.,Pellechia, Perry J.,Palukoshka, Andrei,Wilson, Thomas J.,Tan, Rui,Maier, Josef M.,Greytak, Andrew B.,Smith, Mark D.,Krause, Jeanette A.,Shustova, Natalia B.
, p. 2223 - 2226 (2015/03/04)
Chromophores with a benzylidene imidazolidinone core define the emission profile of commonly used biomarkers such as the green fluorescent protein (GFP) and its analogues. In this communication, artificially engineered porous scaffolds have been shown to mimic the protein β-barrel structure, maintaining green fluorescence response and conformational rigidity of GFP-like chromophores. In particular, we demonstrated that the emission maximum in our artificial scaffolds is similar to those observed in the spectra of the natural GFP-based systems. To correlate the fluorescence response with a structure and perform a comprehensive analysis of the prepared photoluminescent scaffolds, 13C cross-polarization magic angle spinning solid-state (CP-MAS) NMR spectroscopy, powder and single-crystal X-ray diffraction, and time-resolved fluorescence spectroscopy were employed. Quadrupolar spin-echo solid-state 2H NMR spectroscopy, in combination with theoretical calculations, was implemented to probe low-frequency vibrational dynamics of the confined chromophores, demonstrating conformational restrictions imposed on the coordinatively trapped chromophores. Because of possible tunability of the introduced scaffolds, these studies could foreshadow utilization of the presented approach toward directing a fluorescence response in artificial GFP mimics, modulating a protein microenvironment, and controlling nonradiative pathways through chromophore dynamics.
Post-synthetic modification of tagged metal-organic frameworks
Burrows, Andrew D.,Frost, Christopher G.,Mahon, Mary F.,Richardson, Christopher
supporting information; experimental part, p. 8482 - 8486 (2009/04/18)
(Chemical Equation Presented) Playing tag with MOFs: Zinc metal-organic frameworks with pendant aldehyde and methoxy groups are prepared. The aldehyde-tagged MOF takes up 2,4-dinitrophenylhydrazine, reacting to form a hydrazone-functionalized MOF which is crystallographically characterized. Use of both aldehyde- and methoxy-functionalized dicarboxylates leads to MOFs containing both ligands, of which the aldehyde groups can be selectively reacted.
NOVEL COMPOUNDS
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, (2010/11/24)
The present invention is directed to novel compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS
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Page 53, (2008/06/13)
Compounds of formula (I) or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
