858124-35-3

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-bromo-3-formylbenzoate is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new medicinal molecules.
Used in Agrochemical Industry:
Methyl 4-bromo-3-formylbenzoate is used as an intermediate in the synthesis of agrochemicals to aid in the creation of new molecules with agricultural properties.
Used in Organic Synthesis:
Methyl 4-bromo-3-formylbenzoate is used as a building block in organic synthesis for its ability to form new compounds with potential applications in medicine and agriculture.
Used in Research Applications:
Methyl 4-bromo-3-formylbenzoate is used in research applications to explore its properties and potential uses in creating new molecules for various industries.

Upstream product

• 254746-40-2 methyl 4-bromo-3-(hydroxymethyl)benzoate 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 
• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 1095432-84-0 2-bromo-5-(methoxycarbonyl)phenylmethylene diacetate 
• 67-56-1 methanol 
• 877624-37-8 methyl 4-bromo-3-(dibromomethyl)benzoate 
• 142031-67-2 methyl 4-bromo-3-(bromomethyl)benzoate 

Downstream Products

• 776315-23-2 4-bromo-3-formyl-benzoic acid 
• 1620678-03-6 C₁₀H₉BrO₃ 

Relevant academic research and scientific papers

GPR40 AGONISTS

This disclosure is directed, at least in part, to GPR40 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR40 agonists are gut-restricted compounds. In some embodiments, the GPR40 agonists are full agonists or partial agonists. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.

Hydrogen sulfide induced supramolecular self-assembly in living cells

Here we developed a critical gasotransmitter (H2S) mediated reduction to induce supramolecular self-assembly in multiple living cell lines. Specifically, the reduction converted an azido group to an amine which allowed the formation of intramolecular hydrogen bonds. The hydrogen bonds planarized the assembling molecules and promoted the supramolecular self-assembly.

TRICYCLIC PYRI DO-CARBOXAM I D E DERIVATIVES AS ROCK INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates

Mimic of the green fluorescent protein β-barrel: Photophysics and dynamics of confined chromophores defined by a rigid porous scaffold

Chromophores with a benzylidene imidazolidinone core define the emission profile of commonly used biomarkers such as the green fluorescent protein (GFP) and its analogues. In this communication, artificially engineered porous scaffolds have been shown to mimic the protein β-barrel structure, maintaining green fluorescence response and conformational rigidity of GFP-like chromophores. In particular, we demonstrated that the emission maximum in our artificial scaffolds is similar to those observed in the spectra of the natural GFP-based systems. To correlate the fluorescence response with a structure and perform a comprehensive analysis of the prepared photoluminescent scaffolds, 13C cross-polarization magic angle spinning solid-state (CP-MAS) NMR spectroscopy, powder and single-crystal X-ray diffraction, and time-resolved fluorescence spectroscopy were employed. Quadrupolar spin-echo solid-state 2H NMR spectroscopy, in combination with theoretical calculations, was implemented to probe low-frequency vibrational dynamics of the confined chromophores, demonstrating conformational restrictions imposed on the coordinatively trapped chromophores. Because of possible tunability of the introduced scaffolds, these studies could foreshadow utilization of the presented approach toward directing a fluorescence response in artificial GFP mimics, modulating a protein microenvironment, and controlling nonradiative pathways through chromophore dynamics.

Inter- and intramolecular hydroacylation of alkenes employing a bifunctional catalyst system

Based on a conceptually innovative bifunctional P,N ligand, an efficient protocol for the rhodium-catalyzed inter- and intramolecular hydroacylation of alkenes has been developed.

Total synthesis of (-)-martinellic acid via radical addition-cyclization- elimination reaction

(Chemical Equation Presented) The asymmetric total synthesis of martinellic acid, the first pyrrolo[3,2-c]quinoline alkaloid found in nature, is described. Three key steps in our synthesis of (-)-martinellic acid are the Bu 3SnH-promoted radica

Post-synthetic modification of tagged metal-organic frameworks

(Chemical Equation Presented) Playing tag with MOFs: Zinc metal-organic frameworks with pendant aldehyde and methoxy groups are prepared. The aldehyde-tagged MOF takes up 2,4-dinitrophenylhydrazine, reacting to form a hydrazone-functionalized MOF which is crystallographically characterized. Use of both aldehyde- and methoxy-functionalized dicarboxylates leads to MOFs containing both ligands, of which the aldehyde groups can be selectively reacted.

NOVEL FUSED IMIDAZOLE DERIVATIVE

The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A1 and A2, are each a nitrogen atom, and the like; X2, X3, X4, and X5 are all carbon atoms, or alternatively any one of X2, X3, X4, and X5 is a nitrogen atom and the rest are all carbon atoms; R1 is a hydrogen atom, or the like; R2, R3, R4, and R5, are each a hydrogen atom, or the like; R6 and R6', are each a hydrogen atom, and the like; R7 is an aryl group and the like; and R8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.

An improved synthesis of (-)-martinellic acid via radical addition-cyclization-elimination reaction of chiral oxime ether

A concise formal synthesis of (-)-martinellic acid has been accomplished by preparing optically active dipyrroloquinoline as a key synthetic intermediate, which was prepared via the radical addition-cyclization-elimination of oxime ether carrying an unsaturated ester followed by two chemoselective reductions of the carbonyl groups. Georg Thieme Verlag Stuttgart.

NOVEL COMPOUNDS

The present invention is directed to novel compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.