776316-72-4Relevant academic research and scientific papers
Total synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy
Chavan, Subhash P.,Pathak, Ashok B.,Kalkote, Uttam R.
, p. 2635 - 2638 (2007)
The novel cascade intramolecular Pd-catalyzed cyclization followed by aromatization for the construction of D ring of (+)-camptothecin as a key step is demonstrated. Georg Thieme Verlag Stuttgart.
Formal synthesis of (±)-camptothecin via tricyclic lactone as key synthon
Chavan, Subhash P.,Dhawane, Abasaheb N.,Kalkote, Uttam R.
scheme or table, p. 3099 - 3101 (2010/07/18)
Formal synthesis of (±)-camptothecin via CDE tricyclic lactone employing tandem Michael addition, Dieckmann condensation and addition-elimination reaction as key steps starting from glycinate is described.
Formal total synthesis of camptothecin via ring-closing metathesis strategy
Chavan, Subhash P.,Pasupathy,Venkatraman,Kale, Ramesh R.
, p. 6879 - 6882 (2007/10/03)
A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double b
