776324-86-8

Basic information

• Product Name: (3-difluoromethoxy-4-methoxy-phenyl)-acetic acid
• Synonyms: (3-difluoromethoxy-4-methoxy-phenyl)-acetic acid
• CAS NO: 776324-86-8
• Molecular Weight: 232.184
• Mol File: 776324-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-difluoromethoxy-4-methoxy-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-difluoromethoxy-4-methoxy-phenyl)-acetic acid(776324-86-8)
• EPA Substance Registry System: (3-difluoromethoxy-4-methoxy-phenyl)-acetic acid(776324-86-8)

Safety Data

• Hazardous Substances Data: 776324-86-8(Hazardous Substances Data)

Usage

General Description

(3-difluoromethoxy-4-methoxy-phenyl)-acetic acid, also known as Diflunisal, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation. Its chemical structure includes a benzene ring with two methoxy groups and a difluoromethoxy group attached to an acetic acid moiety. Diflunisal works by inhibiting the production of prostaglandins, which are responsible for mediating pain and inflammation in the body. It is commonly used to treat conditions such as arthritis, gout, and menstrual pain. Like other NSAIDs, it may cause side effects such as stomach upset, heartburn, and gastrointestinal bleeding, and it should be used with caution in individuals with a history of peptic ulcers, kidney disease, or heart failure. Overall, Diflunisal is a useful medication for managing pain and inflammation, but it should be used under the supervision of a healthcare professional.

Upstream product

• 1131-94-8 homoisovanillic acid 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 776324-84-6 ethyl (3-difluoromethoxy-4-methoxy-phenyl)-acetate 

Relevant articles and documents

PURIN-6-ONE-DERIVATIVES

The compounds of a certain formula (I) in which e.g. R2, R3, R4 and R5 have the meanings as given below are novel effective PDE2 inhibitors. R2 is hydrogen, 1-4C-alkyl, 1-hydroxy-2-4C-alkyl, 1-4C-alkylcarbonyl or 1-(acetyloxy)-2-4C-alkyl and R3 is Arylbutyl, Heteroarylbutyl, Arylpropyl, Heteroarylpropyl, Arylethyl or Heteroarylethyl; wherein Aryl is phenyl, naphthalenyl or indanyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, Heteroaryl is pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, quinazolinyl, quinoxalinyl, cinnolinyl, quinolyl, isoquinolyl, naphthyridinyl, phthalazinyl, indolyl, isoindolyl, indazolyl, purinyl, pteridinyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrrolyl, pyrazolyl, furanyl or thiophenyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, R4 is 1-4C-alkoxy which is completely or predominantly substituted by fluorine and R5 is halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1 -4C-alkoxy which is completely or predominantly substituted by fluorine, 1-4C-alkoxycarbonyl, amino, mono- or di-1-4C-alkylamino, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkylcarbonylamino, 1-4C-alkylcarbonyloxy, 1-4C-alkylsulfonylamino, phenylcarbonylamino, phenylcarbonylamino substituted in the phenyl moiety by R6 and/or R7, benzylcarbonylamino, benzylcarbonylamino substituted in the phenyl moiety by R8 and/or R9, phenylsulfonylamino, phenylsulfonylamino substituted in the phenyl moiety by R10 and/or R11, benzylsulfonylamino or benzylsulfonylamino substituted in the phenyl moiety by R12 and/or R13.