77638-67-6

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 77638-68-7 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,3-dioxo-1,2,3,4,5,6-hexahydro-indole-3a-carboxylic acid ethyl ester 
• 78982-26-0 (3S,3aS)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-hydroxy-2-oxo-1,2,3,4,5,6-hexahydro-indole-3a-carboxylic acid ethyl ester 
• 78140-32-6 1-<2-(3,4-Dimethoxyphenyl)-ethyl>-2,3-dioxo-2,3,3a,4,5,6-hexahydroindole 

Relevant academic research and scientific papers

A PRACTICAL ROUTE TO SPIRO-TYPE HETEROCYCLES RELATED TO ERYTHRINAN

A new method synthesizing spiro-type heterocycles by intramolecular cyclization of 3,3-disubstituted dioxopyrrolines was presented.The method is particularly useful in synthesizing erythrinans and has the following advantages: 1) it is of short steps with high yield ( one-pot reaction is possible ), 2) an activating group at ring A is not necessary, and 3) the procedure can be carried out without protection of phenolic hydroxyl groups.Wide applicability of this method was also shown by synthesizing C-nor and C-homoerythrinans, and other variants which carry heterocycles at ring A instead of benzenoids.