77651-54-8

Upstream product

• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 77972-18-0 D,L-5-(2'-hydroxyphenyl)hydantoin 
• 271583-17-6 2-amino-2-(2-methoxyphenyl)acetic acid 
• 1439992-51-4 [R,S]5-(2-methoxyphenyl)-3-{1-[4-(2-methoxyphenyl)piperazin-1-yl]methyl}imidazolidine-2,4-dione 
• 1439992-53-6 [R,S]5-(2-methoxyphenyl)-3-{1-[4-(3-(trifluoromethyl)phenyl)piperazin-1-yl]methyl}-imidazolidine-2,4-dione 
• 77651-56-0 methyl (+/-)-2-methoxy-α-<(thioxomethyl)amino>benzene acetate 
• 77651-57-1 (2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester 
• 77651-55-9 2-methoxy phenylglycine methyl ester 

Relevant academic research and scientific papers

ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER

The present invention relates to an isoindolin-1-one derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer, wherein the isoindolin-1-one derivative exhib

A one-pot synthesis of 5,5-disubstituted hydantoin derivatives using magnetic Fe3O4 nanoparticles as a reusable heterogeneous catalyst

A facile and rapid method for the one-pot synthesis of 5,5-disubstituted hydantoins in the presence of magnetic Fe3O4 nanoparticles has been developed. The multicomponent reactions of carbonyl compounds (aldehydes and ketones), potassium cyanide and ammonium carbonate were carried out under solvent-free conditions to obtain various hydantoin derivatives. The magnetic catalyst could be readily separated by an external magnet from the reaction mixture. This procedure has many advantages, such as the use of a reusable magnetic catalyst, high yields, short reaction times, simplicity and very easiness with implementing the methodology.

Novel mannich bases, 5-arylimidazolidine-2,4-dione derivatives with dual 5-HT1A receptor and serotonin transporter affinity

A computer aided ligand design study of imidazolidine-2,4-dione derivatives was conducted in order to obtain compounds with dual 5-HT1A receptor and serotonin transporter (SERT) affinity. According to molecular modeling results, series of Mannich bases were chosen and synthesized. Investigated compounds were tested for 5-HT1A, 5-HT2A, α1 and SERT affinity. Two selected compounds (5, 9) were characterized in functional experiments and possessed a pharmacological profile which may enhance SERT blocking efficacy - 5-HT1A partial agonism and 5-HT2A antagonism in one molecule. Furthermore these compounds displayed satisfactory selectivity over adrenergic α1 receptors. The most promising compounds, 5-arylimidazolidine-2,4-dione derivatives with 4-(3-chlorophenyl)piperazinylmethyl moiety were tested for antidepressant and anxiolytic activity. In particular, compound 5 (5-(2-methoxyphenyl)-3-{1-[4-(3-chlorophenyl)piperazin-1-yl]methyl} -imidazolidine-2,4-dione), tested in the forced swim test in mice, exhibited a favorable antidepressant-like profile without affecting spontaneous locomotor activity. Copyright

Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl-D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers.