77651-54-8

Basic information

• Product Name: 5-(2-methoxyphenyl)imidazolidine-2,4-dione
• Synonyms: 5-(2-methoxyphenyl)imidazolidine-2,4-dione
• CAS NO: 77651-54-8
• Molecular Weight: 206.201
• Mol File: 77651-54-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxyphenyl)imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxyphenyl)imidazolidine-2,4-dione(77651-54-8)
• EPA Substance Registry System: 5-(2-methoxyphenyl)imidazolidine-2,4-dione(77651-54-8)

Safety Data

• Hazardous Substances Data: 77651-54-8(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 271583-17-6 2-amino-2-(2-methoxyphenyl)acetic acid 
• 1439992-51-4 [R,S]5-(2-methoxyphenyl)-3-{1-[4-(2-methoxyphenyl)piperazin-1-yl]methyl}imidazolidine-2,4-dione 
• 1439992-53-6 [R,S]5-(2-methoxyphenyl)-3-{1-[4-(3-(trifluoromethyl)phenyl)piperazin-1-yl]methyl}-imidazolidine-2,4-dione 
• 77651-56-0 methyl (+/-)-2-methoxy-α-<(thioxomethyl)amino>benzene acetate 
• 77651-57-1 (2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester 
• 77651-55-9 2-methoxy phenylglycine methyl ester 
• 77972-18-0 D,L-5-(2'-hydroxyphenyl)hydantoin 

Relevant articles and documents

ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER

The present invention relates to an isoindolin-1-one derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer, wherein the isoindolin-1-one derivative exhib

Novel mannich bases, 5-arylimidazolidine-2,4-dione derivatives with dual 5-HT1A receptor and serotonin transporter affinity

A computer aided ligand design study of imidazolidine-2,4-dione derivatives was conducted in order to obtain compounds with dual 5-HT1A receptor and serotonin transporter (SERT) affinity. According to molecular modeling results, series of Mannich bases were chosen and synthesized. Investigated compounds were tested for 5-HT1A, 5-HT2A, α1 and SERT affinity. Two selected compounds (5, 9) were characterized in functional experiments and possessed a pharmacological profile which may enhance SERT blocking efficacy - 5-HT1A partial agonism and 5-HT2A antagonism in one molecule. Furthermore these compounds displayed satisfactory selectivity over adrenergic α1 receptors. The most promising compounds, 5-arylimidazolidine-2,4-dione derivatives with 4-(3-chlorophenyl)piperazinylmethyl moiety were tested for antidepressant and anxiolytic activity. In particular, compound 5 (5-(2-methoxyphenyl)-3-{1-[4-(3-chlorophenyl)piperazin-1-yl]methyl} -imidazolidine-2,4-dione), tested in the forced swim test in mice, exhibited a favorable antidepressant-like profile without affecting spontaneous locomotor activity. Copyright