77651-55-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy phenylglycine methyl ester is used as an intermediate in the synthesis of various pharmaceuticals for the treatment of diseases and disorders. Its versatile chemical structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Organic Compounds Synthesis:
In addition to its pharmaceutical applications, 2-methoxy phenylglycine methyl ester is also used as an intermediate in the synthesis of other organic compounds. Its unique properties make it a valuable building block for creating a wide range of chemical products.

Upstream product

• 67-56-1 methanol 
• 271583-17-6 2-amino-2-(2-methoxyphenyl)acetic acid 
• 135-02-4 ortho-anisaldehyde 
• 77651-54-8 5-(2-methoxyphenyl)imidazolidine-2,4-dione 

Downstream Products

• 77651-56-0 methyl (+/-)-2-methoxy-α-<(thioxomethyl)amino>benzene acetate 
• 532986-32-6 methyl (2-methoxyphenyl)(octanoylamino)acetate 
• 475475-36-6 [formyl-(2-oxo-ethyl)-amino]-(2-methoxy-phenyl)-acetic acid methyl ester 
• 475475-35-5 (2,2-dimethoxy-ethylamino)-(2-methoxy-phenyl)-acetic acid methyl ester 
• 791630-83-6 [(2,2-dimethoxy-ethyl)-formyl-amino]-(2-methoxy-phenyl)-acetic acid methyl ester 
• 475475-37-7 [formyl-(2-{[methoxycarbonyl-(4-methoxy-phenyl)-methyl]-amino}-ethyl)-amino]-(2-methoxy-phenyl)-acetic acid methyl ester 
• 532986-31-5 N-[2-hydroxy-1-(2-methoxyphenyl)ethyl]octanamide 
• 77651-57-1 (2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester 
• 271583-17-6 2-amino-2-(2-methoxyphenyl)acetic acid 

Relevant academic research and scientific papers

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Synthesis of o,p-EDDHA and its detection as the main impurity in o,o-EDDHA commercial iron chelates

Ethylenediamine-N,N′bis(o-hydroxyphenyl) acetic acid (o,o-EDDHA) is one of the most efficient iron chelates employed to relieve iron chlorosis in plants. However, the presence of positional isomers of EDDHA in commercial iron chelates has been recently demonstrated, and among them, it has been claimed that ethylenediamine-N(o-hydroxyphenylacetic)-N′(p-hydroxyphenylacetic) acid (o,p-EDDHA) is the main impurity present in EDDHA fertilizers. Here we report the preparation of o,p-EDDHA, a compound whose synthesis had not been previously reported. The synthetic o,p-EDDHA is able to form ferric complexes, and it has been used as a standard in the analysis of the impurities of commercial iron fertilizers. The presence of o,p-EDDHA/Fe3+ in commercial samples has been unambiguously demonstrated by HPLC.