77670-05-4Relevant academic research and scientific papers
MECANISME DE L'ADDITION NUCLEOPHILE AU GROUPEMENT CARBONYLE-I. INFLUENCE DE LA NATURE DU SUBSTITUANT POLAIRE SUR LA STEREOCHIMIE ET LA REACTIVITE DANS LES REACTIONS D'ADDITION DE BROMURE DE METHYLMAGNESIUM AUX ARYL-1 PHENYL-2 PROPANONES
Lasperas, M.,Perez-Rubalcaba, A.,Quiroga-Feijoo, M. L.
, p. 3403 - 3408 (2007/10/02)
The influence of a m- or p-polar substituent in 1-aryl 2-phenyl propanones, on addition reactions with CH3MgBr in ether at 30 deg C has been investigated.The invariability of asymmetric induction as a function of substituent, and the correlation of rate constant ratios with Hammett ? constants (ρ=0.24, r=0.97), are consistent with a four-centre pericyclic concerted mechanism with concomitant departure of a solvent molecule.
