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777-11-7

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777-11-7 Usage

Originator

Halotex,Westwood,US,1972

Uses

Different sources of media describe the Uses of 777-11-7 differently. You can refer to the following data:
1. Antibacterial.
2. Haloprogin is a topical antifungal agent used in the treatment of dermatophytic and monilial infections.

Indications

Haloprogin is used as an external drug for moderate dermatophyte infections (shingles), and it is effective for superficial candida infections. Synonyms of this drug are halotex, mycilan, micanden, and others.

Manufacturing Process

4.7 grams of 2,4,5-trichlorophenyl propargyl ether (MP 64° to 65°C) are added to an aqueous solution of cupro-ammonium complex salt which has been prepared by warming a mixture of 4.0 grams of cuprous chloride, 11.0 grams of ammonium carbonate and 20 cc of water to 50°C. The resulting admixture is shaken vigorously. The cuprous acetylide deposited is filtered, washed with water and suspended in 100 cc of water, and the suspension is mixed under agitation with a solution of 5.0 grams of iodine and 5.0 grams of potassium iodide in 15 cc of water. The mixture is stirred for a period of 1 hour. The precipitate is filtered, washed with water and extracted with ether. After the drying of the ethereal extract, the solvent is distilled off. Recrystallization of the residue from n-hexane gives about 5.6 grams of 2,4,5- trichlorophenyi iodopropargyl ether, MP 114° to 115°C.

Brand name

Halotex (Westwood-Squibb).

Therapeutic Function

Antibacterial

General Description

3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.

Synthesis

Haloprogin, 3-iodo-2-propinyl-2,4,5-trichlorophenyl ether (35.4.11), is synthesized by an iodide substitution using a mixture of iodine and potassium iodide and a cupric derivative of 2,4,5-trichlorophenylpropargyl ether (35.4.10), which is synthesized by a standard method from propargyl bromide and 2,4,5-trichlorophenol in the presence of sodium hydroxide.

Check Digit Verification of cas no

The CAS Registry Mumber 777-11-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 777-11:
(5*7)+(4*7)+(3*7)+(2*1)+(1*1)=87
87 % 10 = 7
So 777-11-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2

777-11-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene

1.2 Other means of identification

Product number -
Other names 2,4,5-Trichlor-phenyl-3-jod-2-propinyl-aether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:777-11-7 SDS

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