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777-48-0

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777-48-0 Usage

General Description

3-nitro-4-fluoropropiophenone is a chemical compound with the molecular formula C9H8FNO3. It is a nitrofluorophenone derivative, characterized by the presence of a nitro group and a fluorine substituent on the phenyl ring. This chemical is commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also utilized in the manufacturing of various fine chemicals and research compounds. The compound is known for its reactivity and is handled and stored with care due to its potential hazards. Its properties and structure make it suitable for a range of applications in the chemical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 777-48-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 777-48:
(5*7)+(4*7)+(3*7)+(2*4)+(1*8)=100
100 % 10 = 0
So 777-48-0 is a valid CAS Registry Number.

777-48-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluoro-3-nitrophenyl)propan-1-one

1.2 Other means of identification

Product number -
Other names 3'-NITRO-4'-FLUOROPROPIOPHENONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:777-48-0 SDS

777-48-0Relevant articles and documents

Syntheses and In Vitro Anticancer Properties of Novel Radiosensitizers

Ates-Alagoz, Zeynep,Coleman, Natalia,Martin, Marlena,Wan, Aaron,Adejare, Adeboye

, p. 853 - 861 (2013/01/15)

Series of 4-(ethylsulfonyl)-1-halogen-2-nitrobenzene (3a-e) and 1-(4-halogen-3-nitrophenyl) propan-1-one (5a-d) analogs designed as novel radiosensitizers using bromonitropropiophenone and bromonitrobenzonitrile as lead compounds were synthesized. The anticancer activities of the compounds were evaluated in vitro using human prostate cancer (DU-145) and breast cancer (MCF-7) cell lines and the MTT assay. From the series, six compounds (3b-e, 5b-c) exhibited potent growth inhibitory effects against both cell lines. The most active, compound 3d, is an iodosulfone and is significantly more potent than the lead compound 5c at 10μm. Compounds were then compared with doxorubicin, a clinically used anticancer compound for breast and prostate cancers. Our most active compound 3d is more effective than doxorubicin at the dose level of 10μm at 3days after radiation, cell viabilities of 18%, 13% compared to 87%, 94% against MCF-7, and 15%, 20% compared to 60%, 75% against DU-145 without and with radiation, respectively. At 10μm, compound 5c had no effects as compared to control, whereas compound 3d reduced DU-145 cell viability to 16% and that of MCF-7 cells to 9% even at 5days after radiation. These results are very encouraging. Future studies include testing the compounds in vivo with and without radiation. Our most active compound 3d is significantly more effective than doxorubicin or lead compound 5c at the dose level of 10μm, without and with radiation; and in MCF-7 and DU-145 cell lines. These results are very encouraging. Future studies include testing the compounds in vivo without and with radiation.

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