777047-83-3Relevant academic research and scientific papers
Syntheses of 5-amino-2-phenyl-4(3H)-pyrimidinone derivertives starting with glycine
Takahashi, Daisuke,Honda, Yutaka,Izawa, Kunisuke
, p. 1089 - 1103 (2012)
N-Cbz derivative of 5-amino-2-phenyl-4(3H)-pyrimidinone was prepared from sodium salt of methyl hydroxymethylene glycinate and benzamidine hydrochloride in good yield. However, the reaction with N-substituted benzamidine did not proceed to give the desired pyrimidinone. In contrast, the reaction of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone readily prepared from hippuric acid and N-substituted benzamidine proceeded nicely to give 5-(benzoylamino)-6-oxo-2- phenyl-1(6H)-pyrimidineacetic acid in high yield.
