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Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

Pyrimidine derivatives are a class of organic compounds that have a pyrimidine ring structure, which is a six-membered heterocyclic aromatic ring containing four carbon atoms and two nitrogen atoms.

Explanation

This is an alternative name for the compound, which provides a more detailed description of its structure.

Explanation

The ester functional group is present in the compound, which is formed by the reaction of a carboxylic acid and an alcohol, resulting in the formation of an ester and water.

Explanation

The compound is utilized in the pharmaceutical industry due to its potential biological activities and structural properties, which make it a valuable building block for the development of new drugs.

Explanation

The compound has been studied for its potential applications in medicinal chemistry, which suggests that it may have biological activities that could be useful in the development of pharmaceutical products.

Explanation

As an organic compound, it is primarily composed of carbon, hydrogen, and other elements such as nitrogen and oxygen, which are bonded together to form complex structures.

Class

Pyrimidine derivatives

Functional Group

Ester

Pharmaceutical Industry

Used for the synthesis of various drugs

Biological Activities

Exhibits potential biological activities

Medicinal Chemistry

Studied for potential applications

Organic Compound

Belongs to the class of organic compounds

Upstream product

• 331985-92-3 N-(tert-butoxycarbonylmethyl)benzamidine hydrochloride 
• 634148-47-3 5-(benzoylamino)-6-oxo-2-phenyl-1(6H)-pyrimidineacetic acid tert-butyl ester 
• 124-41-4 sodium methylate 
• 777047-83-3 C₁₃H₁₈N₂O₂ 
• 148747-59-5 5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid 

Downstream Products

• 184710-54-1 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetic acid 
• 356533-99-8 methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate 

Relevant academic research and scientific papers

Syntheses of 5-amino-2-phenyl-4(3H)-pyrimidinone derivertives starting with glycine

N-Cbz derivative of 5-amino-2-phenyl-4(3H)-pyrimidinone was prepared from sodium salt of methyl hydroxymethylene glycinate and benzamidine hydrochloride in good yield. However, the reaction with N-substituted benzamidine did not proceed to give the desired pyrimidinone. In contrast, the reaction of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone readily prepared from hippuric acid and N-substituted benzamidine proceeded nicely to give 5-(benzoylamino)-6-oxo-2- phenyl-1(6H)-pyrimidineacetic acid in high yield.

Design and synthesis of new orally active inhibitors of human neutrophil elastase

To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n showed more potent inhibitory activity than nonpeptidic derivatives 3a-c. As a result, a series of peptidic inhibitors, 4a-s a

Pyridone-based peptidomimetic inhibitors of interleukin-1β-converting enzyme (ICE)

New potent, reversible inhibitors of recombinant human Interleukin-1 β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic replacements for the P2-P3 amino acids of the native substrate and were optimised by manipulation of peripheral alkyl and aryl substituents.