777059-58-2Relevant academic research and scientific papers
Hg/Pt-catalyzed conversion of bromo alkynamines/alkynols to saturated and unsaturated γ-butyrolactams/lactones via intramolecular electrophilic cyclization
Kumar, Yalla Kiran,Kumar, Gadi Ranjith,Reddy, Maddi Sridhar
, p. 1252 - 1260 (2016)
Convenient and general Hg(ii)/Pt(iv) catalyzed syntheses of γ-butyrolactams and α,β-unsaturated γ-butyrolactones/lactams are described via intramolecular electrophilic cyclizations of bromoalkynes with tosylamino and hydroxyl tethers. The reaction features the use of wet solvents, the exclusion of any base and additive, mild conditions and practical yields. We also synthesised few chiral lactams through this pathway. Additionally, it is shown that the NHTs group distanced further from the homopropargylic position assists regioselective bromoalkyne hydration to yield useful α-bromoketones. Furthermore, Boc protected bromo homo propargyl amines undergo 6-endo-dig cyclization through Boc oxygen to give bromomethylene substituted oxazinones.
SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1, 3-DIHYDRO-INDOL-2-ONE'S AND DERIVATIVES THEREOF AS KINASE INHIBITORS
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Page/Page column 152-153, (2010/11/27)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
Regioselective Pd-catalyzed alkylative lactonizations of 4-hydroxy-2-alkynecarboxylates with organoboronic acids
Oh, Chang Ho,Park, Su Jin,Ryu, Jin Hyang,Gupta, Arun Kumar
, p. 7039 - 7042 (2007/10/03)
The Pd-catalyzed addition of organoboronic acids to 4-hydroxy-2- alkynecarboxylates and in situ lactonization gave the butenolides with a high control of regioselectivity.
