7771-20-2Relevant academic research and scientific papers
Reaction of some alkenols with tetrachloromethane
Bugarcic, Zorica M.,Mojsilovic, Biljana,Marjanovic, Ljiljana,Konstantinovic, Stanimir
, p. 1091 - 1096 (2000)
The reaction of some alkenols with tetrachloromethane in the presence of a radical initiator was investigated. Regarding the effects of structural features of the starting alkenol (number and position of methyl substituents at the double bond and at the carbinol carbon atom, constitutional relationship between the double bond and the hydroxyl group) there are two possible competing reactions: addition and cyclization. In the case of the simplest alkenols (without substituents and with a more remote double bond) addition occurs; mono-and disubstituted secondary and tertiary Δ4-and Δ5-alkenols cyclize in high yields to give the corresponding cyclic ethers.
Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
Harris, Jason R.,Waetzig, Shelli R.,Woerpel
experimental part, p. 3290 - 3293 (2009/12/05)
The cyclization of γ, δ-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products. A variety of substrates were screened, and synthetic manipulations were accomplished to construct compounds with structural similarity to antimalarial targets.
