77729-56-7

Upstream product

• 108-24-7 acetic anhydride 
• 505053-16-7 3-methoxycarbonyl-4-(3',5'-dimethoxyphenyl)but-3-enoic acid 
• 115046-50-9 2-[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 74694-98-7 methyl 4,5,7-trimethoxynaphthalene-2-carboxylate 
• 77729-55-6 2-[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester 

Downstream Products

• 78395-68-3 methyl 4-hydroxy-5,7-dimethoxy-2-naphthoate 
• 77729-57-8 4-hydroxy-5,7-dimethoxy-[2]naphthoic acid 
• 78395-62-7 methyl 4-acetoxy-8-iodo-5,7-dimethoxy-2-naphthoate 
• 78395-63-8 methyl 4-hydroxy-8-iodo-5,7-dimethoxy-2-naphthoate 
• 468078-48-0 3-benzyloxy-1,6,8-trimethoxy-naphthalene-2-carboxylic acid 3-bromo-4,5,7-trimethoxy-naphthalen-2-yl methyl ester 
• 74694-98-7 methyl 4,5,7-trimethoxynaphthalene-2-carboxylate 

Relevant academic research and scientific papers

Synthetic Approach to Hypoxyxylerone, Novel Inhibitor of Topoisomerase I

(Equation Presented) A potential route to the topoisomerase I inhibitor hypoxyxylerone is demonstrated by a highly convergent synthesis of the penta(O-methyl) derivative. The key step in the approach is an anionic homo-Fries rearrangement, little used to

The Wittig Reaction of 2-t-Butoxycarbonyl-1-methoxycarbonylethylidenetriphenylphosphorane: A Surrogate for Stobbe Reaction

The reaction of 2-t-butoxycarbonyl-1-methoxycarbonylethylidenetriphenylphosphorane (3) with a range of aromatic aldehydes has been explored.The resultant itaconic esters, obtained in high yield, are readily converted into methyl 4-acetoxynaphthalene-2-carboxylates.

Boron Trichloride as a Selective Demethylating Agent for Hindered Ethers: a Synthesis of the Phytoalexins α- and β-Pyrufuran, a Synthesis of Tri-O-methylleprolomin and its Demethylation

Boron trichloride has been found to be an efficient reagent for the selective cleavage of sterically hindered methoxy groups in methoxyarenes.The scope and utility of this reaction are explored with examples drawn from derivatives of benzene, naphtalene, 9,10-dihydrophenanthrene and dibenzofuran.The method is applied to the synthesis of the phytoalexins α- (56) and β-pyrofuran (58) (1,3,4-trimethoxydibenzofuran-2-ol and 1,2,4-trimethoxydibenzofuran-3-ol).A synthesis of tri-O-methylleprolomin (61), a derivative of the unusual lichen metabolite leprolomin (60), is described and its demethylation with boron trichloride is studied.

Synthesis of a Natural Hexachloro Dinaphthofuran Quinone

1,3,6,8,11,13-Hexachloro-4,10-dihydroxy-5,9-dihydrodinaphthofuran-5,9-dione (1), a pigment isolated from soils and the only natural example of this ring system, has been synthesized for the first time.