74694-98-7

Upstream product

• 77729-57-8 4-hydroxy-5,7-dimethoxy-[2]naphthoic acid 
• 77-78-1 dimethyl sulfate 
• 64766-44-5 methyl 8-iodo-4,5,7-trimethoxy-2-naphthoate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 78395-68-3 methyl 4-hydroxy-5,7-dimethoxy-2-naphthoate 
• 106-65-0 Dimethyl succinate 
• 74694-99-8 dimethyl 2,2',4,4',5,5'-hexamethoxy<1,1'-binaphthalene>-7,7'-dicarboxylate 
• 77729-55-6 2-[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester 
• 77729-56-7 methyl 4-acetoxy-5,7-dimethoxynaphthalene-2-carboxylate 

Downstream Products

• 78395-68-3 methyl 4-hydroxy-5,7-dimethoxy-2-naphthoate 
• 90539-46-1 4,5-Dihydroxy-7-methoxy-naphthalene-2-carboxylic acid methyl ester 
• 64766-44-5 methyl 8-iodo-4,5,7-trimethoxy-2-naphthoate 
• 77729-61-4 4,5,7-trimethoxy-2-naphthoic acid 
• 77729-58-9 methyl 8-nitro-4,5,7-trimethoxy-2-naphthoate 
• 77729-56-7 methyl 4-acetoxy-5,7-dimethoxynaphthalene-2-carboxylate 
• 468078-48-0 3-benzyloxy-1,6,8-trimethoxy-naphthalene-2-carboxylic acid 3-bromo-4,5,7-trimethoxy-naphthalen-2-yl methyl ester 
• 97944-85-9 methyl 4,5-diacetoxy-7-methoxynaphthalene-2-carboxylate 

Relevant academic research and scientific papers

Process for the manufacture of hypoxyxylerone derivatives

The present invention relates to the total synthesis of hypoxyxylerone derivatives (formula I) and their biological activities. R1-R5 are as described in the description.

Synthetic Approach to Hypoxyxylerone, Novel Inhibitor of Topoisomerase I

(Equation Presented) A potential route to the topoisomerase I inhibitor hypoxyxylerone is demonstrated by a highly convergent synthesis of the penta(O-methyl) derivative. The key step in the approach is an anionic homo-Fries rearrangement, little used to

The Thermal Elimination of Iodine from Some Substituted α-Iodonaphthalenes: a Structural Study

Brief heating of a number of methyl 8-iodo-5,7-dimethoxy-2-naphthoate derivatives with a variety of added hydroxy-, methoxy-, or acetoxy-substituents in the 4- and 6-positions has been found to result in facile elimination of iodine in certain compounds but not others; subsequent examination of other aspects of the chemistry of the system have suggested this to be a solid state effect.Single crystal X-ray structure determinations have been carried out on a representative selection of compounds, suggesting that in those examples where elimination has been found to occur, intimate charge-transfers interactions between the conjugated systems of adjacent molecules arising from the nature of the crystal packing are responsible; in those compounds which do not eliminate iodine, similar interactions may also be found but are associated with substituent out-of-plane steric interactions which hinder relative movement of the naphthalene moieties in the lattice.

SYNTHESIS OF A NATURAL POLYCHLORO DINAPHTHOFURAN QUINONE

The hexachloro dinaphthofuran quinone (1), the only natural example of this ring system has been synthesised for the first time.

Synthesis of a Natural Hexachloro Dinaphthofuran Quinone

1,3,6,8,11,13-Hexachloro-4,10-dihydroxy-5,9-dihydrodinaphthofuran-5,9-dione (1), a pigment isolated from soils and the only natural example of this ring system, has been synthesized for the first time.