77747-14-9

Upstream product

• 10352-30-4 2,6-dichloro-4-phenylquinoline 
• 106-47-8 4-chloro-aniline 
• 3158-99-4 1-phenyl-1-(2-amino-5-chlorophenyl)ethylene 
• 592-82-5 butyl isothiocyanate 
• 536-74-3 phenylacetylene 
• 76303-65-6 3-(n-Butyl)-6-chlor-3,4-dihydro-4-hydroxy-2-methyl-4-phenylchinazolin 

Relevant academic research and scientific papers

Base-controlled chemoselectivity reaction of vinylanilines with isothiocyanates for synthesis of quinolino-2-thione and 2-aminoquinoline derivatives

Here, we report a base-controlled chemo-selective reaction of vinylanilines with alkyl/aryl isothiocyanates to afford quinolino-2-thione and 2-aminoquinoline derivatives. The quinolino-2-thiones could be obtained in high yields in the presence of Et3N. Particularly interesting is that the reaction could produce the 2-aminoquinolines in the presence of K3PO4 with high selectivity.