10352-30-4

Upstream product

• 30169-33-6 6-Chlor-1,2-dihydro-4-phenylchinolin-2-on 
• 13788-59-5 N-(2-benzoyl-4-chlorophenyl)acetamide 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 106-47-8 4-chloro-aniline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 962-08-3 N-(4-chlorophenyl)-3-oxo-3-phenylpropanamide 
• 30169-33-6 6-chloro-4-phenyl-2-quinolinone 

Downstream Products

• 76093-58-8 6-Chloro-4-phenyl-2-piperazin-1-yl-quinoline 
• 31576-85-9 6-chloro-2-(4-methyl-piperazin-1-yl)-4-phenyl-quinoline 
• 32676-11-2 6-chloro-4-phenyl-2-(4-phenyl-piperazin-1-yl)-quinoline 
• 31577-08-9 6-Chlor-2-(2-hydroxyethylamino)-4-phenylchinolin 
• 31576-98-4 6-Chlor-2-dimethylamino-4-phenylchinolin 
• 37171-92-9 2-(2-Diethylaminoethylamino)-6-chlor-4-phenylchinolin 
• 27537-93-5 6-chloro-2-hydrazino-4-phenylquinoline 
• 77747-14-9 2-(n-Butylamino)-6-chlor-4-phenylchinolin 
• 75158-63-3 C₁₇H₁₂ClN₃O 
• 36916-18-4 7-Chloro-1-methyl-5-phenyl-s-triazolo<4,3-a>quinoline 
• 36916-19-5 5-chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone 
• 36916-20-8 4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde 
• 57698-44-9 7-chloro-5-phenyl-s-triazolo<4,3-a>quinoline 
• 1314518-54-1 tert-butyl (2Z)-2-[6-chloro-4-phenylquinolin-2(1H)-ylidene]-2-cyanoacetate 

Relevant academic research and scientific papers

Pyrrolopyrrole cyanines: Effect of substituents on optical properties

To tune their optical properties, a large variety of pyrrolopyrrole cyanines (PPCys) were synthesized with substitutedheteroaromatics such as quinoline, benzothiazole, and oxazole derivatives as terminal groups. Thus, a broad range of stable, highly fluorescing near-infrared (NIR) dyes with high absorptivities between 690 to 845 nm is accessible. The large number of newly synthesized compounds allows a detailed discussion of the correlation between molecular structure and the optical properties of the first electronic transition. Syntheses and optical properties of pyrrolopyrrole cyanines (PPCys) with different substituents at the terminal heteroaromatic moieties are described. The relationship between molecular structure and optical properties is discussed. By suitable substitution, the absorption and fluorescence maxima of the chromophore can be tuned in a range between 690 and 845 nm. Copyright

Synthesis and anticonvulsant activity of 5-phenyl-[1,2,4]-triazolo[4,3-a] quinolines

A series of novel 5-phenyl-[1,2,4]-triazolo[4,3-a]quinoline derivatives was synthesized by the cyclization of 2-chloro-4-phenyl-1,2-dihydronaphthalene with formohydrazide. The starting material 2-chloro-4-phenyl-1,2-dihydronaphthalene was synthesized from ethyl-3-oxo-3-phenylpropanoate and substituted aniline. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). The maximal electroshock test showed that 7-hexyloxy-5-phenyl-[1,2,4]- triazolo[4,3-a]quinoline 4f was found to be the most potent compound with an ED50 value of 6.5 mg/kg and a protective index (PI = ED 50/TD50) value of 35.1, which was much higher than the PI of the reference drug phenytoin.

2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones

A process to make 6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines by converting 2-[3-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenones to 2-[3-[(phthalimido or methanesulfonyl)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and converting these compounds to the highly active 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines useful as tranquilizers and sedatives.

Triazolyl benzophenone compounds

Intermediates of the formula IV: STR1 wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, and R4 are selected from the group consisting of hydrogen, fluoro, chloro, bromo, nitro, and trifluoromethyl are produced by a multistep synthesis. The final compounds are tranquilizers and sedatives and can be used in mammals, including man, and in birds.