77756-26-4Relevant academic research and scientific papers
Generation and Synthetic Utility of Dianions Derived from Thiophencarboxylic Acids
Knight, David W.,Nott, Andrew P.
, p. 791 - 794 (2007/10/02)
Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropylamide in tetrahydrofuran at -78 deg C.The resulting dianionic species react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.
Formation and reactivity of dianions derived from 2- and 3-thiophencarboxylic acids
Knght, David W.,Nott, Andrew P.
, p. 5051 - 5054 (2007/10/02)
Dianions (3) and (6) can be generated in high yield from the corresponding thiophencarboxylic acids with lithium diisopropylamide and react with a number of representative electrophiles to give fair to good yields of 5-substituted-thiophen-2-carboxylic acids and 2-substituted thiophen-3-carboxylic acids respectively.
