77766-06-4

Upstream product

• 1005-38-5 4-amino-6-chloro-2-methylthiopyrimidine 
• 98-80-6 phenylboronic acid 
• 15760-26-6 3-cyano-2-methylisothiourea 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS

This application relates to compounds of Formula (I) or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Pyrimidine Derivatives. II. New Synthesis and Reactions of 4-Amino-2-methylthiopyrimidine Derivatives

4-Amino-2-methylthiopyrimidine derivatives (4) were synthesized by the cyclization of 3-cyano-2-methylisothiourea (2) with ketones (3).Oxidation of 4 produced 4-amino-2-methylsulfinyl or 2-methylsulfonylpyrimidine derivatives (7 or 8).Amination of 7 or 8 gave hypoglycemic 2-(1-piperazinyl)pyrimidines (1).Compounds 4 were converted to 4(3H)-pyrimidinone derivatives (12).Derivatives 1 were also synthesized via 12.Keywords - hypoglycemic drug; base-catalyzed cyclization; 3-cyano-2-methylisothiourea; 4-amino-2-methylthiopyrimidines; 4-amino-2-methylthio-5,6,7,8-tetrahydroquinazoline; 2-methylthio-4(3H)-pyrimidinones; 2-methylsulfinylpyrimidines amination; 2-methylsulfonylpyrimidines amination