77778-16-6Relevant academic research and scientific papers
Palladium precatalysts containing meta-terarylphosphine ligands for expedient copper-free Sonogashira cross-coupling reactions
Yang, Yong,Lim, Joyce Fen Yan,Chew, Xinying,Robins, Edward G.,Johannes, Charles W.,Lim, Yee Hwee,Jong, Howard
, p. 3501 - 3506 (2015/07/01)
Three novel palladium complexes utilizing different variations of the evolutionary meta-terarylphosphine ligand, CyPhine, were developed. These air- and moisture-stable complexes, PdCl2L2 (L = CyPhine, CyPhine-CF3 and CyPhine-nBu), demonstrated exceptional broad-based performance and operational simplicity in the copper-free Sonogashira cross-coupling of challenging (hetero-)aryl chlorides and terminal alkynes. Modifications to the periphery of the ligand scaffold showed modest improvements in the reaction rate when more electron-donating substituents were incorporated, which hints at potential design upgrades in the future.
5b,7b-diaza-3b,9b-diborabenzo[ghi]perylenes
Bosdet, Michael J.D.,Piers, Warren E.,Sorensen, Ted S.,Parvez, Masood
experimental part, p. 426 - 433 (2010/09/16)
Treatment of a precursor to the chelating Lewis acid 2,2′- diborabiphenyl with 2,6-bisalkynyl-substituted pyridazines, leads to elimination of 2 equiv. of ClSiMe3; subsequent treatment of the mixture with PtCl2 catalyzes the cyclizat
Highly selective mono-substitution in Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine with organozinc compounds
Chekmarev, Dmitriy S.,Stepanov, Alexander E.,Kasatkin, Alexander N.
, p. 1303 - 1305 (2007/10/03)
Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.
Pyrazolopyridine adenosine antagonists
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Page column 30, (2008/06/13)
The present invention relates to a novel pyrazolopyridine compound of the following formula: whereinR1 is aryl, andR2 is cyclo(lower)alkyl which may have one or more suitable substituent(s), etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said pyrazolopyridine compound or a salt thereof; a pharmaceutical composition comprising said pyrazolopyridine compound or a pharmaceutically acceptable salt thereof; etc.
