77779-08-9Relevant articles and documents
Heterocyclic compounds, processes for their preparation and their use
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, (2008/06/13)
Thiophene carboxamides are described of general formula I STR1 in which the amide function is in the 2- or 3-position on the thiophene ring, R1 to R5 inclusive are hydrogen atoms or lower alkyl groups, X is --CH2 --, --O-- or --NR6 -- where R6 is hydrogen or a lower alkyl group, n is a number from 0 to 3 and Ar is an optionally substituted phenyl group and their physiologically acceptable salts. The compounds have been found to lower blood pressure in animals and to exhibit a blocking action at β-adrenoreceptors and their use is indicated for the treatment of cardiovascular disorders such as hypertension and angina. Some of the compounds also exhibit a blocking action on α-adrenoreceptors and their use is indicated for the treatment of hypertention.