77783-90-5Relevant academic research and scientific papers
Efficient and Clean Nickel Catalyzed α-Allylation Reaction of Nitriles
Mouhsine, Bouchaib,Karim, Abdallah,Dumont, Clément,Suisse, Isabelle,Sauthier, Mathieu
, p. 1457 - 1462 (2021)
A clean method has been developed for the α-allylation of phenyl and alpha alkyl phenyl acetonitrile with allylic alcohols. The reaction is catalyzed by nickel complexes in situ generated from a combination of Ni(cod)2 and the dppf ligand and performed at 80 °C in methanol as reaction solvent.Accordingly to this simple and base-free protocol that only yields water as a side-product, many allylic nitriles were synthetized with good yields. (Figure presented.).
A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromans
Wang, Yingwei,Li, Guangxun,Liu, Hongxin,Tang, Zhuo,Cao, Yuan,Zhao, Gang
supporting information, p. 10652 - 10655 (2017/10/06)
An unprecedented method that enables the direct coupling of an α-C-H bond in alcohols with 2-arylacetaldehydes through a [1,3]-hydride transfer ([1,3]-HT) of oxocarbenium ions catalyzed by a Lewis acid has been developed. The redox neutral preparation of
Applications of Substituted Arylacetaldehydes in the Total Synthesis of Mesembrane Alkaloids. Part 2. An Alternative Systhesis of (+/-)-Sceletium Alkaloid A4
Forbes, Craig P.,Wenteler, George L.
, p. 29 - 32 (2007/10/02)
The substituted arylacetaldehydes (+/-)-2-(3,4-dimethoxyphenyl)pent-4-enal (1c) is shown to serve as a precursor in the total synthesis of the mesembrane alkaloid (+/-)-sceletium alkaloid A4.
