777934-45-9Relevant academic research and scientific papers
Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors
Powell, Noel A.,Clay, Emma H.,Holsworth, Daniel D.,Bryant, John W.,Ryan, Michael J.,Jalaie, Mehran,Edmunds, Jeremy J.
, p. 4713 - 4716 (2005)
Inhibition of renin enzymatic activity by a series of ketopiperazine-based compounds containing a C6 benzyloxymethyl substituent correlated with a +(π + σ) effect. A 3-pyridinyloxymethyl substituent was also found to be equipotent as higher molecular weig
PIPERAZINE DERIVATIVE RENIN INHIBITORS
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Page 62-63, (2010/02/09)
Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):
