777935-95-2Relevant academic research and scientific papers
Copper(II) terpyridine complexes: Effect of substituent on DNA binding and nuclease activity
Uma, Varadarajan,Elango, Munusamy,Nair, Balachandran Unni
, p. 3484 - 3490 (2007)
Mononuclear copper(II) terpyridine complexes, [Cu(ttpy)-Cl]Cl (1) and [Cu(itpy)Cl]Cl (2) (ttpy = tolylterpyridine and itpy = imidazolylterpyridine) were synthesized and characterized. The interaction of the complexes with DNA was studied by electronic and CD spectroscopy, viscosity and gel electrophoresis. Absorption titrations, viscosity and CD experiments reveal an intercalative mode of DNA binding for these complexes. The binding constant values for 1 and 2 are (5.6 ± 0.2) × 104 and (1.4 ± 0.2) × 104 M-1, respectively, and suggest moderate binding of these complexes to DNA. From computational studies, it was found that the aromatic π cloud is more uniformly distributed in the case of tolylterpyridine (complex 1), which possibly leads to better stacking interactions with the DNA bases and hence a higher binding constant value for complex 1. From the gel electrophoresis experiments, it is inferred that both complex 1 and 2 cleave plasmid DNA in the presence of ascorbic acid and the cleavage efficiency of complex 1 is greater than that of complex 2. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Synthesis and Crystal Structure of A Novel Mixed-valent Tri-copper Complex of 4′-p-Tolyl-2,2′:6′,2′-terpyridine
Wang, Song,Li, Bao-Ding,Wang, Rui-Ying,Wu, Ben-Lai,Zhang, Hong-Yun
, p. 355 - 359 (2011/03/17)
Two copper complexes of 4′-p-tolyl-2,2′:6′,2′- terpyridine (ttpy), namely, monomer [CuII(ttpy)Cl2] (1) and trinuclear complex [CuII(ttpy)Cl2]. [Cu IICuI(ttpy)Cl3] (2), were prepared through solvothermal synthesis and structurally determined by single crystal X-ray diffraction. Compound 1 obtained by another way before was firstly solvothermally synthesized and structurally investigated herein. In 1 metal center Cu2+ ligated by a ttpy molecule and two chloride ions is in a distorted square pyramidal geometry. However, complex 2 is a novel mixed-valent tri-copper complex which contains a monomeric [CuII(ttpy)Cl 2] part being very similar to 1, and a mixed-valent chloride-bridged di-nuclear [CuIICuI(ttpy)Cl3] part, presented interesting co-crystallization behavior.
