7781-49-9Relevant academic research and scientific papers
Synthesis, crystal structure and antiradical effect of copper(ii) Schiff base complexes containing five-, six- and unusual seven-membered rings
Puterova, Zita,Valentova, Jindra,Bojkova, Zuzana,Koiek, Jozef,Devinsky, Ferdinand
, p. 1484 - 1490 (2011)
The synthesis and solid-state structure of mononuclear copper(ii) complexes [Cu(SAIB)(H2O)2] (1), [Cu(SBAIB)(H2O) 2]·H2O (2) and [Cu(SGABA)(H2O) 2] (3) are described. Schiff base
In vitro studies regarding the antioxidant effects of procaine, gerovital H3 and aslavital
Gradinaru, Daniela,Margina, Denisa,Borsa, Claudia
experimental part, p. 761 - 766 (2010/09/03)
Gerovital H3 (GH3) and Aslavital are Romanian procaine based drugs used in the prophylaxis of aging for over 40 years. By the use of in vitro experimental models, the main purpose of the present study was to evaluate the antioxidant effects of these anti-aging products with regard to the superoxide radical generation in an enzymatic system, xanthine - xanthine oxidase - INT [2-(4-iodophenyl)-3-(4-nitrophenol)-5-phenyltetrazolium chloride], as well as with regard to the susceptibility of human low density lipoprotein to oxidation (oxLDL), corresponding to conjugated dienes formation. At 10 mM in reference to procaine concentration, the maximum of inhibition was exerted by Aslavital (88%) followed by GH3 (62%), whereas procaine hydrochloride had a slight inhibitory effect upon the INT reduction. We pointed out a significant inhibition of Cu2+- induced oxLDL after 20 and 60 minutes in the presence of Aslavital at all the concentrations tested (0.1; 0.5 and 1 mM, related to procaine final concentration in the reaction system), while GH3 exerted a significant decrease in oxLDL only at the highest concentration (1mM procaine).
