77817-51-7

Basic information

• Product Name: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-, methyl ester
• CAS NO: 77817-51-7
• Molecular Formula: C15H14ClNO2
• Molecular Weight: 275.735
• Mol File: 77817-51-7.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-, methyl ester(77817-51-7)
• EPA Substance Registry System: Benzoic acid, 4-chloro-2-[(2-methylphenyl)amino]-, methyl ester(77817-51-7)

Safety Data

• Hazardous Substances Data: 77817-51-7(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 212892-02-9 methyl 4-chloro-2-(((trifluoromethyl)sulfonyl)oxy)benzoate 
• 50-84-0 2,4 dichlorobenzoic acid 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 5106-98-9 4-chlorosalicylic acid 
• 67-56-1 methanol 
• 32305-28-5 4-chloro-2-o-toluidino-benzoic acid 

Downstream Products

• 75412-49-6 4-Chloro-2-o-tolylamino-benzoic acid [1-(4,5-dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-43-0 4-Chloro-2-o-tolylamino-benzoic acid [1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-42-9 4-Chloro-2-o-tolylamino-benzoic acid [1-(2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-48-5 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-47-4 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-45-2 4-Chloro-2-o-tolylamino-benzoic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-46-3 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 75412-44-1 4-Chloro-2-o-tolylamino-benzoic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 32305-28-5 4-chloro-2-o-toluidino-benzoic acid 
• 75412-39-4 4-Chloro-2-o-tolylamino-benzoic acid hydrazide 

Relevant articles and documents

Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum

A parallel synthetic strategy to the 9-aminoacridine scaffold of the classical anti-malarial drug quinacrine (2) is presented. The method features a new route to 9-chloroacridines that utilizes triflates of salicylic acid derivatives, which are commercially available in a variety of substitution patterns. The route allows ready variation of the two diversity elements present in this class of molecules: the tricyclic aromatic heterocyclic core, and the disubstituted diamine sidechain. In this study, a library of 175 compounds was designed, although only 93 of the final products had purities acceptable for screening. Impurity was generally due to incomplete removal of 9-acridones (18), a degradation product of the 9-chloroacridine synthetic intermediates. The library was screened against two strains of Plasmodium falciparum, including a model of the drug-resistant parasite, and six novel compounds were found to have IC50 values in the low nanomolar range.

Synthesis and Biological Activity of Some Substituted Diphenylamine-2-carboxylic Acid Derivatives

Twenty-four N-benzylidene-5-chlorodiphenylamine-2-carboxylic acid hydrazides (IV) have been synthesized by condensation of substituted 5-chlorodiphenylamine-2-carboxylic acid hydrazides (III) with different aromatic aldehydes.All the compounds have been s