77819-83-1

Usage

Common use

Reagent in chemical synthesis for the production of various pharmaceutical and industrial compounds

Importance

Used in the formation of amides, esters, and other functional groups in organic chemistry

Additional use

Phase transfer catalyst in various organic syntheses and reactions

Safety

Important to handle and store with appropriate safety measures to prevent potential health hazards or environmental impact

Upstream product

• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 100-52-7 benzaldehyde 
• 74696-96-1 3-acetyl-7-diethylaminocoumarin 

Relevant academic research and scientific papers

Designing novel inhibitors against falcipain-2 of Plasmodium falciparum

Coumarin containing pyrazoline derivatives have been synthesized and tested as inhibitors of in vitro development of a chloroquine-sensitive (MRC-02) and chloroquine-resistant (RKL-2) strain of Plasmodium falciparum and in vivo Plasmodium berghei malaria. Docking study was also done on cysteine protease falcipain-2 which showed that the binding pose of C-14 molecule and epoxysuccinate, inhibitor of falcipain-2, binds in the similar pattern. The most active antimalarial compound was 3-(1-benzoyl-5-(4-flurophenyl)-4,5-dihydro-1H-pyrazol-3yl)-7-(diethyamino)-2H-chromen-2-one C-14, with an IC50 of 4.21 μg/ml provided complete protection to the infected mice at 24 mg/kg X 4 days respectively.

Synthesis and fluorescent properties of coumarin–chalcone hybrids

Four coumarin–chalcone hybrids were synthesised utilising condensation of acetylcoumarin with three benzaldehydes and cinnamaldehyde, respectively. Moreover, the absorption and fluorescence spectra of these synthesised compounds in dichloromethane were me

Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect

A series of novel fluorescent pyrazoline coumarin derivatives were synthesized. From them, we screened a compound possessing strong growth inhibitory effects on lung cancer cells. By taking advantage of fluorescence combined with LC-MS/MS and chemoinforma

Fluorescence turn-on probe for biothiols: Intramolecular hydrogen bonding effect on the Michael reaction

Weakly fluorescent coumarinyl enones are rapidly transformed into strongly fluorescent molecules through the Michael addition reaction of a thiol group, where an intramolecular hydrogen bond plays a critical role in the reaction rate. The molecular probe