77838-08-5

Basic information

• Product Name: N-hydroxybenzotriazole ester of N-Boc-6-aminohexanoic acid
• Synonyms: N-hydroxybenzotriazole ester of N-Boc-6-aminohexanoic acid
• CAS NO: 77838-08-5
• Molecular Weight: 348.402
• Mol File: 77838-08-5.mol

Chemical Properties

• CAS DataBase Reference: N-hydroxybenzotriazole ester of N-Boc-6-aminohexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxybenzotriazole ester of N-Boc-6-aminohexanoic acid(77838-08-5)
• EPA Substance Registry System: N-hydroxybenzotriazole ester of N-Boc-6-aminohexanoic acid(77838-08-5)

Safety Data

• Hazardous Substances Data: 77838-08-5(Hazardous Substances Data)

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 54769-59-4 N-hydroxybenzotriazole ester of benzenesulfonic acid 
• 2592-95-2 benzotriazol-1-ol 

Downstream Products

• 69936-59-0 p-(N-Boc-6-aminohexanoyl)amino-phenyl-β-L-fucopyranoside 
• 154561-43-0 Boc-Acp-Tyr-OMe 
• 1263819-90-4 N-((N-chlorambucilylamino)hexanoyl)-p-hydroxyphenyl-L-p-tyrosinamide 
• 1260612-26-7 N-[6-(N-chlorambucilamino)hexanoyl]-L-p-tyrosine methyl ester 
• 1263819-88-0 N-((N-Boc-amino)hexanoyl)-p-hydroxyphenyl-L-p-tyrosinamide 

Relevant articles and documents

ANTICANCER AGENTS BASED ON AMINO ACID DERIVATIVES

The present invention provides compounds of formula (I): in which T is L or -A-NH-C(O)-L-; L is -(CH2)n- or -(CH2)p-Z-; A is -(CH2)m- or an alkyl component of a naturally occurring amino acid; R is -CO2R1, -CH2OH, -C(O)NH(hydroxyphenyl) or C(S)NH(hydroxyphenyl); R1 is H or is C1-C12 alkyl; X is -OH, OSO2R2, -Cl, -Br, or -I; R2 is C1-C12 alkyl or -CF3; Z is phenyl or naphthyl; m is an integer having a value of 1 to 20; n is an integer having a value of 1 to 20; and p is an integer having a value of 1 to 20 or an enantiomer, diastereoisomer, racemic mixture, pharmaceutically acceptable salt, solvate or prodrug thereof. These compounds can be useful as anticancer agents.

Selective stabilization of AT-rich DNA-DNA duplexes by oligodeoxyribonucleotide conjugates with distamycin analogues

Oligodeoxyribonucleotide conjugates with distamycin analogues containing up to five pyrrolecarboxamide moieties were synthesized. The stability of duplexes formed by these conjugates was shown to depend directly upon the number of pyrrolecarboxamide moieties in the ligand molecule. For the duplexes formed by octaadenylate and octathymidilate conjugates with the distamycin pentapyrrole analogue, stability was demonstrated to be achieved by either one or two ligand molecules; however, duplexes containing two ligand molecules are more stable.