77841-63-5Relevant academic research and scientific papers
Fused cycloalkyl amides and acids and their therapeutic applications
-
, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
Fused cycloalkyl amides and acids and their therapeutic applications
-
, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
DIRECT CONVERSION OF ALKENES INTO METHYL-SUBSTITUTED CYCLOPROPANES USING AN ORGANOIRON ETHYLIDENE TRANSFER REAGENT
Kremer, Kenneth A. M.,Helquist, Paul
, p. 231 - 252 (2007/10/02)
(η5-C5H5)(CO)2FeCH(CH3)SPh (8) serves as a quite useful reagent for the transfer of ethylidene groups to alkenes to give methyl-substituted cyclopropanes in good yields.The reaction is accomplished by allowing 8 to react with an alkylating agent such as trimethyloxonium tetrafluoroborate or methyl fluorosulfonate in the presence of the alkene substrate.The active ethylidene transfer reagent is apparently a sulfonium salt which is too reactive to be isolated under normal conditions.In all csases, cyclopropanes are obtained stereospecifically with respect to the configuration of the starting alkenes, and with certain classes of substrates such as cis-disubstituted alkenes, the reaction also occurs with very high syn-stereoselectivity.
Thermal valence isomerization of cis-fused bicyclic cyclobutenes. A study of orbital symmetry control
Dauben, William G.,Michno, Drake M.
, p. 2284 - 2292 (2007/10/19)
This study shows that thermally promoted valence isomerizations of cis-fused bicyclic cyclobutenes, when free of steric constraint, yield products arising from both orbital symmetry allowed conrotatory openings of the labile σ bond in the cyclobutene ring. In the case of the related vinylcyclobutenes, one conrotatory mode produces a stable cis,trans,cis monocyclic triene whereas fission in the other allowed sense affords a thermally labile trans,cis,cis monocyclic triene which, in turn, cyclizes to yield a cyclohexadiene derivative. The product distributions are evaluated in terms of secondary orbital interactions.
