77844-21-4

Upstream product

• 121895-78-1 2-[(1S,5R)-1-(4-Methoxy-phenyl)-5-trimethylsilanyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide 
• 238421-61-9 (3R,5S)-3-(4-methoxyphenyl)-3-(3-oxobutyl)-5-(2-propyl)-2,4(3H,5H)-furadione 
• 238421-40-4 (5S)-4-hydroxy-3-(4-methoxyphenyl)-5-(2-propyl)-2(5H)-furanone 
• 121960-60-9 2-[(R)-1-(4-Methoxy-phenyl)-4-oxo-cyclohex-2-enyl]-N,N-dimethyl-acetamide 
• 121895-79-2 (-)-(1S,5S)-3-(p-methoxyphenyl)-5-trimethylsilyl-2-cyclohexen-1-ol 
• 121960-61-0 (S)-3-(4-Methoxy-phenyl)-5-trimethylsilanyl-cyclohex-2-enone 
• 238421-75-5 (3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-3-(4-methoxyphenyl)-N-methyl-N-(benzyloxycarbonyl)heptanamide 
• 238421-74-4 (3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-3-(4-methoxyphenyl)-N-(benzyloxycarbonyl)heptanamide 
• 238421-77-7 [(S)-3-[1,3]Dioxolan-2-yl-3-(4-methoxy-phenyl)-5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-methyl-carbamic acid benzyl ester 
• 238421-78-8 [(S)-3-Hydroxymethyl-3-(4-methoxy-phenyl)-5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-methyl-carbamic acid benzyl ester 
• 238421-71-1 (1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol 
• 238421-73-3 methyl (2E,4S)-4-(tert-butyldimethylsilyloxymethyl)-7,7-ethylenedioxy-4-(4-methoxyphenyl)-2-octenoate 
• 238421-72-2 (2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal 

Downstream Products

• 77784-04-4 O-methyl dihydrojoubertiamine 

Relevant academic research and scientific papers

2(3H)-and 2(5H)-furanones. VII. Chirality transfer on the tetronic acid templates

The chirality transfer on the β-tetronic acid templates has been examined via highly diastereoselective alkylation or the Michael reaction at the α-position of the acids. Synthetic utility of this transfer procedure was demonstrated by the formal synthesis of (+)-cassiol and enantiodivergent synthesis of O-methyljoubertiamine.

Synthesis of (R)-(-)-O-Methyljoubertiamine

The title compound was synthesized by utilizing sigmatropic rearrangement of 3-substituted 2-cyclohexenol derivative for the construction of optically active quaternary carbon center.