77855-76-6

Basic information

• Product Name: PEG6-(CH2CO2H)2
• Synonyms: PEG6-(CH2CO2H)2;HOOCCH2O-PEG5-CH2COOH;3,6,9,12,15,18-Hexaoxaeicosanedioic acid
• CAS NO: 77855-76-6
• Molecular Formula: C₁₄H₂₆O₁₀
• Molecular Weight: 354.35024
• Mol File: 77855-76-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 524.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.234±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water
• PKA: 3.09±0.10(Predicted)
• CAS DataBase Reference: PEG6-(CH2CO2H)2(CAS DataBase Reference)
• NIST Chemistry Reference: PEG6-(CH2CO2H)2(77855-76-6)
• EPA Substance Registry System: PEG6-(CH2CO2H)2(77855-76-6)

Safety Data

• Hazardous Substances Data: 77855-76-6(Hazardous Substances Data)

Usage

Description

PEG6-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Upstream product

• 4792-15-8 Pentaethylene glycol 
• 211746-79-1 di-tert-butyl 3,6,9,12,15,18-hexaoxaicosane-1,20-dioate 

Relevant articles and documents

Effective Na+-Binding Ability and Molecular Assembly of an Alkylamide-Substituted Penta(ethylene)glycol Derivative

A new amphiphilic penta(ethylene glycol) derivative (1) bearing two hydrogen-bonding -CONHC14H29 chains was prepared. Compound 1 exhibited ion-recognition abilities for Na+ and K+, and its properties were compared with those of the macrocyclic [18]crown-6. Although both compound 1 and [18]crown-6 have six ether oxygen atoms (-OC2H2-), the Na+-binding ability of the former was much higher than that of the latter. K+-binding ability of cyclic [18]crown-6 was much higher than its Na+-binding ability, while the reverse was true for acyclic compound 1. Single-crystal X-ray structural analysis of Na+·1·B(Ph)4-·(hexane)2 at 100 K revealed the existence of a wrapped Na+-coordination by six ether and one carbonyl oxygen atoms of 1, which was further stabilized by intramolecular N-H···O= hydrogen-bonding interactions. The complex phase transition during glass (G) formation and recrystallization was confirmed in the thermal cycle of Na+·1·B(Ph)4-, whose molten state showed two kinds of liquid phases, Na+-complexed (Na+·1) + B(Ph)4- and completely dissociated Na+ + 1 + B(Ph)4-. The Na+ conductivity of the molten state was 2 orders of magnitude higher than that of the G phase.

ALBUMIN-BINDING COMPOUNDS

The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.