778567-10-5

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 365462-75-5 2-amino-3-nitrophenyl 4-(4-methyl-1,4-diazepan-1-yl)benzoate hydrochloride 
• 365462-76-6 N-(2-hydroxy-6-nitrophenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide 
• 42457-22-7 5-methoxythiophene-2-carbonyl chloride 
• 365462-77-7 N-(2-amino-6-hydroxyphenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide 

Downstream Products

• 365462-37-9 N-(3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]-amino}phenyl)-5-methoxythiophene-2-carboxamide hydrochloride 

Relevant academic research and scientific papers

Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor

Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported findings from our optimization study of a high-throughpu