778577-38-1

Upstream product

• 621-23-8 1,2,3-trimethoxybenzene 
• 3157-65-1 N-(p-chlorobenzylidene)-p-toluenesulfonamide 
• 104-88-1 4-chlorobenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 178946-89-9 bis(3-indolyl)-4-chlorophenylmethane 
• 1426243-79-9 2-(1-(4-chlorophenyl)but-3-enyl)-1,3,5-trimethoxybenzene 
• 1426243-80-2 2-((4-chlorophenyl)(2,4,6-trimethoxyphenyl)methyl)-1,3-diphenylpropane-1,3-dione 
• 86694-53-3 5-[(4-chlorophenyl)(5-methyl-2-furyl)methyl]-2-methylfuran 
• 1426243-81-3 5,5'-((4-chlorophenyl)methylene)bis(2-methylthiophene) 

Relevant academic research and scientific papers

Synthesis method of N-diarylmethyl sulfonamide compound

The invention discloses a synthesis method of an N-diarylmethyl sulfonamide compound, and belongs to the technical field of organic synthesis intermediates. According to the synthesis method, the N-diarylmethyl sulfonamide compound is synthesized by utilizing a cascade reaction; the method specifically comprises the following steps: (1) adding an aromatic aldehyde, a sulfonamide, trimethoxybenzeneor a derivative thereof, and Lewis acid into a reaction tube according to a molar ratio of 1.0: 1.0: 1.0: 0.1, and carrying out magnetic stirring reaction at room temperature for 8-24 hours by taking1, 2-dichloroethane as a solvent; and (2) after the reaction is finished, evaporating under reduced pressure to remove most of the solvent, and carrying out column chromatography separation and purification on a residual mixed solution by using petroleum ether and ethyl acetate in a volume ratio of (1: 1)-(2: 1) as leacheate to obtain the product. The N-diarylmethyl sulfonamide compound synthesized by the method has wide application in the fields of medicines, pesticides and the like. The synthesis method disclosed by the invention has the advantages of low cost, simplicity in operation, highyield, mild conditions and the like, and has a good application prospect.

Heterobimetallic Ir-Sn catalysis: Aza-Friedel-Crafts reaction of N-sulfonyl aldimines

The heterobimetallic complex [Ir(COD)(SnCl3)Cl(μ-Cl)] 2 catalyzes the aza-Friedel-Crafts reaction of 1,3,5- trimethoxybenzene, as well as substituted indoles with N-sulfonyl aldimines leading to the formation of diarylamines and triarylmethanes in good yields. The symmetrical triarylmethanes were also obtained from diarylamines and suitable nucleophiles via simultaneous cleavage of sp3 C-N bond and elimination of 1,3,5-trimethoxybenzene.

Ruthenium porphyrin catalyzed friedel-crafts type reaction of arenes with imines

Cationic ruthenium porphyrin complex was found to be an efficient catalyst for the Friedel-Crafts type reaction of arenes with imines. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and weakly coordinating axial ligand is the key to bring out the catalytic reactivity of ruthenium for the reaction.

Friedel-crafts arylation reactions of N -sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes catalyzed by FeCl 3·6H2O: Synthesis of triarylmethanes and bis-heteroarylarylmethanes

(Figure presented) The FeCl3·6H2O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroar