778577-40-5Relevant academic research and scientific papers
Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines
Beisel, Tamara,Diehl, Andreas M.,Manolikakes, Georg
, p. 4116 - 4119 (2016)
A general Pd-catalyzed, enantioselective three-component synthesis of α-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of α-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected α-arylglycines.
