778580-45-3Relevant academic research and scientific papers
Efficient palladium-catalyzed cross-coupling of β-chloroalkylidene/ arylidene malonates using microwave chemistry
Poondra, Rajamohan R.,Fischer, Peter M.,Turner, Nicholas J.
, p. 6920 - 6922 (2007/10/03)
A general method for the synthesis of β-aryl/ alkylarylidene malonates is reported. The key step involves the coupling of an arylboronic acid to a β-chloroalkyl/ arylidene malonate, in the presence of K2CO 3 and 1 mol % of the air-stable palladium catalyst (POPd) under microwave irradiation, to afford β-aryl/alkylarylidene malonates in good yields. The combination of mild reaction conditions, air stable catalyst, microwave-enhanced chemistry, and high levels of functional group compatibility make this an attractive synthetic approach to this class of compounds.
