778595-07-6

Upstream product

• 224578-18-1 2,2-Dimethyl-propionic acid (3R,7R)-3-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-7-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-5-methylene-heptyl ester 
• 224578-16-9 2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde 
• 88920-24-5 p-methoxybenzyloxy acetic acid 

Downstream Products

• 224578-36-3 2,2-Dimethyl-propionic acid (3R,7S)-3-(tert-butyl-dimethyl-silanyloxy)-8-{(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-5-methylene-7-(toluene-4-sulfonyloxy)-octyl ester 
• 778595-10-1 2,2-Dimethyl-propionic acid (3R,7S)-8-{(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-3-hydroxy-5-methylene-7-(toluene-4-sulfonyloxy)-octyl ester 
• 224578-22-7 2,2-Dimethyl-propionic acid (3R,7S)-3-(tert-butyl-dimethyl-silanyloxy)-8-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-7-hydroxy-5-methylene-octyl ester 
• 224578-23-8 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester 
• 224575-43-3 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(diisopropoxy-phosphorylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester 
• 224578-38-5 2,2-Dimethyl-propionic acid 2-{(2R,6R)-6-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-(2-iodomethyl-oxazol-4-yl)-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester 
• 224578-37-4 2,2-Dimethyl-propionic acid 2-{(2R,6R)-6-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-(2-hydroxymethyl-oxazol-4-yl)-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester 
• 224578-20-5 2,2-Dimethyl-propionic acid 2-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester 
• 224578-35-2 2-{(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethanol 
• 224578-21-6 {(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-acetaldehyde 
• 1027565-70-3 2,2-Dimethyl-propionic acid (3R,7R)-7-hydroxy-3-methanesulfonyloxy-7-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-5-methylene-heptyl ester 
• 224578-32-9 2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester 
• 224578-34-1 2,2-Dimethyl-propionic acid 2-{(2R,4R,6R)-4-hydroxy-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester 
• 224578-19-2 2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester 

Relevant academic research and scientific papers

Synthetic studies toward Phorboxazole A. Stereoselective synthesis of the C3-C19 and C20-C32 subunits

A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral allylstannanes followed by stereoselective cyclizations. The pentasubstituted tetrahydropyran of the C20-C32 fragment is prepared via an intramolecular stereoselective cationic cyclization of a methoxymethyl ether derivative.