778598-29-1Relevant academic research and scientific papers
A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from transpentacin
Abraham, Elin,Bailey, Callum W.,Claridge, Timothy D.W.,Davies, Stephen G.,Ling, Kenneth B.,Odell, Barbara,Rees, Thomas L.,Roberts, Paul M.,Russell, Angela J.,Smith, Andrew D.,Smith, Lorna J.,Storr, Helen R.,Sweet, Miles J.,Thompson, Amber L.,Thomson, James E.,Tranter, George E.,Watkin, David J.
experimental part, p. 1797 - 1815 (2010/10/05)
The solid state and solution phase conformational preferences of a homologous series of β-peptides derived from (S,S)-2- aminocyclopentanecarboxylic acid (transpentacin) have been investigated using a variety of spectroscopic and crystallographic techniqu
A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones
Balázs, árpád,der Eycken, Erik Van,Fül?p, Ferenc
, p. 4333 - 4335 (2008/12/21)
An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed, microw
Evaluating β-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction
Davies, Stephen G.,Russell, Angela J.,Sheppard, Ruth L.,Smith, Andrew D.,Thomson, James E.
, p. 3190 - 3200 (2008/03/14)
A systematic study of the effect of substitution within the β-amino acid framework indicates that both β2- and β3- amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained β-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to l-proline. The Royal Society of Chemistry.
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan,Jia, Shaojuan,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 6178 - 6182 (2008/04/02)
As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were
A novel preparation of 2-aminocyclopentanecarboxamides
Csomos, Peter,Bernath, Gabor,Fueloep, Ferenc
, p. 1077 - 1084 (2007/10/03)
Different syntheses of cis- and trans-2-aminocyclopentanecarboxamides were studied. A convenient and effective method was devised for the preparation of cis-2-aminocyclopentanecarboxamide derivatives starting from the readily available 6-tert-butoxycarbon
Preparation of cycloalkane-fused dihydropyrimidin-4(3H)-one enantiomers
Szakonyi, Zsolt,Fueloep, Ferenc,Bernath, Gabor,Toeroek, Gabriella,Peter, Antal
, p. 993 - 999 (2007/10/03)
Racemic cis-2-amino-1-cyclopentane- or -cyclohexane-1-carboxylic acid was reacted with (R)-α-methylbenzylamine to form homochiral amides 3, 4 and 8, 9. The ring closures of 3, 4 and 8, 9 with aryl imidates resulted in cyclopentane cis-fused and cyclohexane cis- and trans-fused dihydropyrimidin- 4-one enantiomers with loss of the N-substituent. The absolute configurations were determined by hydrolysis of 5, 6 and 10-13 to the corresponding amino acids.
