778602-85-0Relevant academic research and scientific papers
Synthesis of α-alkylidene-γ-butyrolactones via ring-cleavage/recyclization of 2-amino-4,5-dihydro-3-furancarboxamides
Okabe, Fumi,Tagawa, Yoshinobu,Yamagata, Kenji
, p. 505 - 508 (2007/10/03)
The reactions of 2-amino-4,5-dihydro-3-furancarboxamides 1a,b with cyanomethylene compounds (such as alkyl cyanoacetates and malononitrile) gave the corresponding ring-opened products 2a-f. Compounds 2a-d reacted with methanesulfonic acid to give the corresponding α-alkylidene-γ- butyrolactones 3a-d. On the other hand, treatment of 2e,f with methanesulfonic acid yielded 3-pyridinecarbonitrile derivatives 4a,b.
