778625-56-2Relevant academic research and scientific papers
On the Origins of Nonradiative Excited State Relaxation in Aryl Sulfoxides Relevant to Fluorescent Chemosensing
Kathayat, Rahul S.,Yang, Lijun,Sattasathuchana, Tosaporn,Zoppi, Laura,Baldridge, Kim K.,Linden, Anthony,Finney, Nathaniel S.
supporting information, p. 15889 - 15895 (2016/12/22)
We provide herein a mechanistic analysis of aryl sulfoxide excited state processes, inspired by our recent report of aryl sulfoxide based fluorescent chemosensors. The use of aryl sulfoxides as reporting elements in chemosensor development is a significan
Investigation of steric and electronic effects in the copper-catalysed asymmetric oxidation of sulfides
O'Mahony, Graham E.,Eccles, Kevin S.,Morrison, Robin E.,Ford, Alan,Lawrence, Simon E.,Maguire, Anita R.
supporting information, p. 10168 - 10184 (2013/11/06)
Steric and electronic effects in the copper-catalysed asymmetric oxidation of aryl benzyl, aryl alkyl and alkyl benzyl sulfides have been investigated. The presence of an aryl group directly attached to the sulfur is essential to afford sulfoxides with high enantioselectivities, with up to 97% ee for 2-naphthyl benzyl sulfoxide, the highest enantioselectivity achieved to date for copper-catalysed asymmetric sulfoxidation. In contrast, the benzyl substituent can be replaced by sterically comparable groups with no effect on enantioselectivity. Copper-mediated oxidation of substituted aryl benzyl sulfides display modest steric and electronic effects resulting in comparable or lower enantioselectivities to those obtained with the unsubstituted benzyl phenyl sulfide.
Copper-catalyzed asymmetric oxidation of sulfides
O'Mahony, Graham E.,Ford, Alan,Maguire, Anita R.
experimental part, p. 3288 - 3296 (2012/05/20)
Copper-catalyzed asymmetric sulfoxidation of aryl benzyl and aryl alkyl sulfides, using aqueous hydrogen peroxide as the oxidant, has been investigated. A relationship between the steric effects of the sulfide substituents and the enantioselectivity of th
Chiral sulfoxides as metabolites of 2-thioimidazole-based p38α mitogen-activated protein kinase inhibitors: Enantioselective synthesis and biological evaluation
Bühler, Stefanie,Goettert, Marcia,Schollmeyer, Dieter,Albrecht, Wolfgang,Laufer, Stefan A.
supporting information; experimental part, p. 3283 - 3297 (2011/06/26)
Figure Presented. A number of pharmaceutically important drugs contain asymmetric sulfinyl moieties, so the biological evaluation of chiral sulfoxides as human drug metabolites is important for the development of safe and effective pharmaceuticals. Asymme
Enantioselective vanadium-catalyzed oxidation of 1,3-dithianes from aldehydes and ketones using β-amino alcohol derived schiff base ligands
Wu, Yinuo,Mao, Fei,Meng, Fanchao,Li, Xingshu
supporting information; experimental part, p. 1707 - 1712 (2011/10/01)
The asymmetric vanadium-catalyzed oxidation of 1,3-dithianes from aldehydes and ketones by β-amino alcohol-derived Schiff base ligands with two stereogenic centers was investigated. Using aqueous hydrogen peroxide as the oxidant and the Schiff base 3b as
