778628-25-4Relevant academic research and scientific papers
Synthesis of modified Weinreb amides: N-tert-butoxy-N-methylamides as effective acylating agents
Labeeuw, Olivier,Phansavath, Phannarath,Genêt, Jean-Pierre
, p. 7107 - 7110 (2004)
An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.
