778649-56-2

Upstream product

• 90-02-8 salicylaldehyde 
• 166263-27-0 2-isopropoxy-5-nitro-benzaldehyde 
• 1754-88-7 ethylenetriphenylphosphorane 
• 19182-96-8 2-allyl-4-nitrophenol 
• 1568-66-7 1-allyloxy-4-nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 75-30-9 2-iodo-propane 
• 103851-62-3 β-methyl-2-hydroxy-5-nitrostyrene 

Relevant academic research and scientific papers

Nitration under continuous flow conditions: Convenient synthesis of 2-isopropoxy-5-nitrobenzaldehyde, an important building block in the preparation of nitro-substituted Hoveyda-Grubbs metathesis catalyst

Herein, we describe the use of continuous flow chemistry for selective, efficient and reproducible nitration of 2-isopropoxybenzaldehyde to produce the desired 2-isopropoxy-5-nitrobenzaldehyde, an important building block in the preparation of a ligand of nitro-substituted Hoveyda-Grubbs metathesis catalyst. Nitration was done with red fuming HNO3, and this challenging and hazardous process was performed using a flow-through silicon-glass microreactor equipped with a set of temperature sensors, and with a productivity of 13 g/h, providing us with a reproducible chemical process amenable for production of sufficient quantities of 2-isopropoxy-5-nitrobenzaldehyde for ongoing large-scale synthesis of nitro-substituted Hoveyda-Grubbs metathesis catalyst.

Ortho- and para-substituted Hoveyda-Grubbs carbenes. An improved synthesis of highly efficient metathesis initiators

A novel highly efficient and general route to various 3- and 5-substituted 2-alkoxystyrenes, required for the preparation of Hoveyda-Grubbs catalysts, is described.