77868-31-6Relevant academic research and scientific papers
Synthesis and Structure - Activity Relationships of Sweet 2-Benzoylbenzoic Acid Derivatives
Arnoldi, Anna,Bassoli, Angela,Borgonovo, Gigliola,Merlini, Lucio,Morini, Gabriella
, p. 2047 - 2054 (2007/10/03)
Twenty-four analogues of the sweet compound 2-(4-methoxybenzoyl)benzoic acid 1 were synthesized and tasted. The structure-sweet taste relationships were studied by means of principal component analysis and by comparison with the existing sweet receptor models. Three possible glucophores were identified, which could correspond to the sites B, E1, and E2 of the Tinti - Nofre model. Some similarities between this class of compounds and isovanillic sweeteners were found.
Studies in Rearrangement of 2-(Arylthio)benzohydroxamic Acids to the Corresponding 2-(Arylsulphinyl)benzamides
Dhareshwar, G. P.,Chhaya, P. N.,Hosangadi, B. D.
, p. 831 - 835 (2007/10/02)
2-(2'-Methoxyphenylthio)-(III)-, 2-(4'-methoxyphenylthio)-(IV)-, 2-(2'-methylphenylthio)-(V)- and 2-(4'-methylphenylthio)-(VI)-benzohydroxamic acids on treatment with polyphosphoric acid yield 2-(2'-methoxyphenylsulphinyl)-(VII)-, 2-(4'-methoxyphenylsulphinyl)-(VIII)-, 2-(2'-methylphenylsulphinyl)-(IX)- and 2-(4'-methylphenylsulphinyl)-(X)-benzamides respectively, illustrating the generality of rearrangement reported earlier .The rearrangement can also be effected with other reagents like xylene-P2O5, perchloric acid- gl. acetic acid and trifluoracetic acid. 2-Methylthiobenzohydroxamic acid (XI) and 4-(phenylthio)benzohydroxamic acid (XII) when treated with PPA yield benzothiazolone (XIII) and 4-aminodiphenyl sulphide (XIV).Experimental evidence has been presented which points to a concerted mechanism for the intramolecular oxygen transfer.
