77868-77-0

Usage

Uses

Used in Organic Synthesis:
N-benzyl-2,4-dibromobutamide is employed as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical entities through reactions such as substitution, addition, and condensation, contributing to the development of novel pharmaceuticals and specialty chemicals.
Used in Chemical Research:
In the realm of chemical research, N-benzyl-2,4-dibromobutamide is used as a valuable building block for the exploration of new chemical reactions and mechanisms. Its reactivity and structural features make it an ideal candidate for studying reaction pathways and understanding the fundamental principles of organic chemistry.
Used in Pharmaceutical Development:
N-benzyl-2,4-dibromobutamide is used as a starting material in the development of new pharmaceuticals. Its potential medicinal properties have led to investigations into its use as an anticonvulsant, which could help in the treatment of epilepsy and other seizure disorders. Additionally, its potential as an antidyskinetic agent suggests it may be useful in managing movement disorders such as dystonia and chorea.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-benzyl-2,4-dibromobutamide is utilized for the design and synthesis of new drug candidates. Its unique structural features and reactivity make it a promising scaffold for the development of compounds with therapeutic potential, particularly in the areas of neurology and movement disorders.
Overall, N-benzyl-2,4-dibromobutamide is a versatile chemical compound with applications spanning across various industries, including organic synthesis, chemical research, pharmaceutical development, and medicinal chemistry. Its potential as a building block for new compounds and its medicinal properties make it a valuable asset in the ongoing pursuit of scientific advancements and therapeutic solutions.

Upstream product

• 82820-87-9 2,4-dibromobutanoyl chloride 
• 100-46-9 benzylamine 
• 52412-07-4 2,4-dibromo-butyryl bromide 

Downstream Products

• 77868-84-9 1-benzyl-3-bromo-pyrrolidin-2-one 
• 5336-34-5 3-hydroxy-1-benzyl-2-pyrrolidinone 
• 100372-86-9 3-acetoxy-1-benzyl-2-pyrrolidinone 
• 6837-27-0 (+/-)-1-benzyl-3-phenylpyrrolidin-2-one 
• 190778-54-2 3-(3'-benzyloxy-1'-propenylidene)-N-benzylpyrrolidin-2-one 

Relevant academic research and scientific papers

Reductive Alkylation of Tertiary Lactams via Addition of Organocopper (RCu) Reagents to Thioiminium Ions

A simple procedure for the conversion of tertiary lactams to 2-monoalkylated cyclic amines is described. The reaction sequence involves conversion of a lactam to a thioiminium ion followed by reaction with an organocopper (RCu) reagent and final reduction with triacetoxyborohydride. The reaction is high yielding and shows an excellent functional group tolerance. Its utility is demonstrated by a rapid synthesis of indolizidine 167B. The excellent chemoselectivity of the process, where only monoalkylation products are formed, is rationalized by a mechanism involving the formation of a transient enamine.

Cobalt-Catalyzed Cross-Coupling of α-Bromo Amides with Grignard Reagents

A cobalt-catalyzed cross-coupling between α-bromo amides and Grignard reagents is disclosed. The reaction is general and allows access to a large variety of α-aryl and β,γ-unsaturated amides. Some mechanistic investigations have been undertaken to determine the nature of the intermediate species.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.

Cephalosporin derivatives

The present invention relates to compounds of formula I STR1 wherein R1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily hydroyzable esters thereof, pharmaceutically acceptabl

Synthesis of β-enaminoesters and lactams by Michael addition of N- benzylaniline to new allenic esters and lactams

The synthesis of original allenic lactams 2 and allenic esters 5 is presented and their Michael condensation with N-benzylaniline described.

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation