77868-78-1

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 1450-81-3 2,5-dibromopentanoic acid 
• 41339-29-1 2,5-Dibromo-pentanoyl chloride 
• 62-53-3 aniline 

Downstream Products

• 77868-85-0 3-bromo-1-phenylpiperidin-2-one 
• 161754-81-0 (2R,6R,7R)-7-tert-Butoxycarbonylamino-8-oxo-3-[2-oxo-1-phenyl-piperidin-(3E)-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid benzhydryl ester 
• 161675-44-1 (6R,7R)-7-tert-Butoxycarbonylamino-8-oxo-3-[2-oxo-1-phenyl-piperidin-(3E)-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-gen

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation