1450-81-3

Basic information

• Product Name: 2,5-DIBROMOVALERIC ACID
• Synonyms: 2,5-DIBROMOVALERIC ACID;2,5-Dibromopentanoicacid
• CAS NO: 1450-81-3
• Molecular Formula: C₅H₈Br₂O₂
• Molecular Weight: 259.92
• Mol File: 1450-81-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 208.75°C (rough estimate)
• Flash Point: 140.1 °C
• Appearance: /
• Density: 1.8629
• Vapor Pressure: 0.000157mmHg at 25°C
• Refractive Index: 1.5347 (estimate)
• Solubility: DCM, DMSO, Methanol
• CAS DataBase Reference: 2,5-DIBROMOVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIBROMOVALERIC ACID(1450-81-3)
• EPA Substance Registry System: 2,5-DIBROMOVALERIC ACID(1450-81-3)

Safety Data

• Hazardous Substances Data: 1450-81-3(Hazardous Substances Data)

Usage

Uses

2,5-Dibromopentanoic Acid is used in the synthesis of inhibitors for aminoglycoside resistant bacteria. Also used in the preparation of sequence specific base pair mimics as topoisomerase IB inhibitors.

InChI:InChI=1/C5H8Br2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3H2,(H,8,9)

Upstream product

• 4221-03-8 5-hydroxypentanal 
• 6280-87-1 δ-chlorovaleronitrile 
• 13392-69-3 valeric acid 
• 2067-33-6 5-bromopentanoic acid 
• 694-54-2 tetrahydro-2H-2-pyranol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 54288-59-4 diethyl 2-bromo-2-(3-bromopropyl)malonate 
• 7726-95-6 bromine 
• 10035-10-6 hydrogen bromide 

Downstream Products

• 178933-83-0 C₉H₁₆Br₂O₂ 
• 77868-79-2 N-benzyl-2,5-dibromopentanamide 
• 77868-85-0 3-bromo-1-phenylpiperidin-2-one 
• 77868-78-1 2,5-Dibromo-pentanoic acid phenylamide 
• 77868-86-1 3-bromo-1-benzyl-2-piperidinone 
• 609-36-9 rac-Pro-OH 

Relevant articles and documents

Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors

The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of either or both processes in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1β converting enzyme (“ICE”).

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation